NOS3

Gene Symbol	NOS3
Entrez Gene	4846
Alt Symbol	ECNOS, eNOS
Species	Human
Gene Type	protein-coding
Description	nitric oxide synthase 3 (endothelial cell)
Other Description	EC-NOS|NOS type III|NOSIII|cNOS|constitutive NOS|endothelial NOS|nitric oxide synthase 3 transcript variant eNOS-delta20|nitric oxide synthase 3 transcript variant eNOS-delta20-21|nitric oxide synthase 3 transcript variant eNOS-delta21|nitric oxide synthase, endothelial
Swissprots	Q14251 Q6GSL5 A8KA63 Q14434 A0S0A8 B2RCQ1 P29474 E9PFR2 Q13662 Q9UDC6 A0S0A7 Q548C1
Accessions	AAA36365 AAA36373 AAA36374 AAB87083 AAK71989 AAL07497 AAM74944 ABY87544 BAA05652 CAA53950 CDI44688 EAL24494 EAW54069 P29474 AF400594 AAK83389 AI082109 AK223636 BAD97356 AK225827 AK292928 BAF85617 AK300390 BAH13275 AK302686 BAH13779 AK315213 BAG37648 BC063294 AAH63294 BC069465 AAH69465 BU731828 CB987955 DA859819 DQ256129 ABB79838 DQ256130 ABB79839 DQ256131 ABB79840 HQ257992 ADR82746 JX853577 AFX88320 JX853578 AFX88321 JX853579 AFX88322 M93718 AAA36364 M95296 AAA36372 S80791 AAD14336 XM_006716002 XP_006716065 NM_000603 NP_000594 NM_001160109 NP_001153581 NM_001160110 NP_001153582 NM_001160111 NP_001153583
Function	Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Subcellular Location	Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
Tissue Specificity	Platelets, placenta, liver and kidney. {ECO:0000269|PubMed:7515611}.
Top Pathways	Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Oxytocin signaling pathway, Estrogen signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-eNOS (Ser1177) Sandwich ELISA Kit - 7980 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

Pig NOS3 / eNOS ELISA Kit (Sandwich ELISA) - LS-F4245 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 6.1 pg/ml Range 1.56-100 ng/ml

Mouse/Human/Rat NOS3 / eNOS ELISA Kit (Cell-Based ELISA) - LS-F3310 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 1.56-100 ng/ml

Rat NOS3 / eNOS ELISA Kit (Sandwich ELISA) - LS-F4107 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 1.56-100 ng/ml

Human NOS3 / eNOS ELISA Kit (Sandwich ELISA) - LS-F4106 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 1.56-100 ng/ml

Mouse NOS3 / eNOS ELISA Kit (Sandwich ELISA) - LS-F4108 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 1.56-100 ng/ml

Mouse/Human/Rat Phospho-NOS3 / eNOS (Thr494) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1498 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 1.56-100 ng/ml

Mouse/Human/Rat Phospho-NOS3 / eNOS (Ser1176) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1497 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 1.56-100 ng/ml

Mouse/Human/Rat Phospho-NOS3 / eNOS (Ser615) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1416 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 1.56-100 ng/ml

Human NOS3 / eNOS ELISA Kit (Sandwich ELISA) - LS-F12170 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 78 pg/ml Range 1.56-100 ng/ml

Dog NOS3 / eNOS ELISA Kit (Sandwich ELISA) - LS-F12171 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 3.12 Range 1.56-100 ng/ml

Pig NOS3 / eNOS ELISA Kit (Sandwich ELISA) - LS-F12172 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 3.12 Range 1.56-100 ng/ml

Human eNOS ELISA Kit - abx054268 from Abbexa Category ELISA Kit

Endothelial nitric oxide synthase, eNOS, Human, ELISA Kit - CSB-E08322h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.27 IU/ml Range 1.1 IU/ml-70 IU/ml

Nitric Oxide Synthase 3, Endothelial (NOS3), Human, ELISA Kit - SEA868Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 5.5pg/mL Range 15.6-1,000pg/mL

Human eNOS ELISA Kit - HN0031 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine eNOS ELISA Kit - AN0031 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

eNOS Colorimetric Cell-Based ELISA - CB6154 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

eNOS (Phospho-Ser615) Colorimetric Cell-Based ELISA Kit - CBP1447 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

eNOS (Phospho-Ser1176) Colorimetric Cell-Based ELISA Kit - CBP1542 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

eNOS (Phospho-Thr494) Colorimetric Cell-Based ELISA Kit - CBP1543 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human eNOS ELISA Kit - DEIA2819 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of eNOS is typically less than 25 pg/mL.

Endothelial nitric oxide synthase, ELISA Kit - MBS280616 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Endothelial nitric oxide synthase - MBS283219 from MyBioSource Category ELISA Kit

Endothelial Nitric Oxide Synthase (eNOS), ELISA Kit - MBS260626 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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