NOS3

Gene Symbol	NOS3
Entrez Gene	4846
Alt Symbol	ECNOS, eNOS
Species	Human
Gene Type	protein-coding
Description	nitric oxide synthase 3 (endothelial cell)
Other Description	EC-NOS|NOS type III|NOSIII|cNOS|constitutive NOS|endothelial NOS|nitric oxide synthase 3 transcript variant eNOS-delta20|nitric oxide synthase 3 transcript variant eNOS-delta20-21|nitric oxide synthase 3 transcript variant eNOS-delta21|nitric oxide synthase, endothelial
Swissprots	Q14251 Q6GSL5 A8KA63 Q14434 A0S0A8 B2RCQ1 P29474 E9PFR2 Q13662 Q9UDC6 A0S0A7 Q548C1
Accessions	AAA36365 AAA36373 AAA36374 AAB87083 AAK71989 AAL07497 AAM74944 ABY87544 BAA05652 CAA53950 CDI44688 EAL24494 EAW54069 P29474 AF400594 AAK83389 AI082109 AK223636 BAD97356 AK225827 AK292928 BAF85617 AK300390 BAH13275 AK302686 BAH13779 AK315213 BAG37648 BC063294 AAH63294 BC069465 AAH69465 BU731828 CB987955 DA859819 DQ256129 ABB79838 DQ256130 ABB79839 DQ256131 ABB79840 HQ257992 ADR82746 JX853577 AFX88320 JX853578 AFX88321 JX853579 AFX88322 M93718 AAA36364 M95296 AAA36372 S80791 AAD14336 XM_006716002 XP_006716065 NM_000603 NP_000594 NM_001160109 NP_001153581 NM_001160110 NP_001153582 NM_001160111 NP_001153583
Function	Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Subcellular Location	Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
Tissue Specificity	Platelets, placenta, liver and kidney. {ECO:0000269|PubMed:7515611}.
Top Pathways	Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Oxytocin signaling pathway, Estrogen signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

eNOS peptide - ab109090 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human eNOS full length protein - ab198066 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human eNOS protein fragment - ab112329 from Abcam Category Protein Source Wheat germ Species Human

eNos-Antibody-S1177-Blocking-peptide - BP11828a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-eNosS1177-Antibody-Blocking-peptide - BP3665a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

NOS3-Antibody-N-term-Blocking-Peptide - BP6963a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

eNOS Blocking Peptide - 33R-10759 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

eNOS (phospho-Ser1177) Blocking Peptide - abx063012 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit, Sheep

eNOS Blocking Peptide - abx063013 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Rabbit, Sheep

Human NOS3 Protein - abx068308 from Abbexa Category Protein Source E.coli Species Human

NOS3 - H00004846-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NOS3 - H00004846-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Nitric Oxide Synthase 3, Endothelial (NOS3), Human - 20-7265 from ARP American Research Products Category Protein Prices $505.00 Sizes 50 µg Source E.coli Species Human

Nitric Oxide Synthase 3, Endothelial (NOS3), Human - 20-7266 from ARP American Research Products Category Protein Prices $505.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human Nitric Oxide Synthase 3 (Endothelial Cell) - NOS3-635H from Creative Biomart Category Protein Source Sf9 cells.

Recombinant Human NOS3 - NOS3-28567TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Nitric Oxide Synthase 3, Endothelial (NOS3) - RPA868Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Nitric Oxide Synthase 3, Endothelial (NOS3) - RPA868Hu03 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Nitric Oxide Synthase 3, Endothelial (NOS3) - RPA868Hu04 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Nitric Oxide Synthase 3, Endothelial (NOS3) - RPA868Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Nitric Oxide Synthase 3, Endothelial (NOS3) - RPA868Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Nitric Oxide Synthase 3, Endothelial (NOS3) - RPA868Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Nitric Oxide Synthase 3, Endothelial (NOS3) - RPA868Rb01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rabbit

Recombinant Nitric Oxide Synthase 3, Endothelial (NOS3) - RPA868Ca01 from Uscn Life Science Inc. Category Protein Source E.coli Species Dog

Recombinant Nitric Oxide Synthase 3, Endothelial (NOS3) - RPA868Po01 from Uscn Life Science Inc. Category Protein Source E.coli Species Pig

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