NOS3

Gene Symbol NOS3
Entrez Gene 4846
Alt Symbol ECNOS, eNOS
Species Human
Gene Type protein-coding
Description nitric oxide synthase 3 (endothelial cell)
Other Description EC-NOS|NOS type III|NOSIII|cNOS|constitutive NOS|endothelial NOS|nitric oxide synthase 3 transcript variant eNOS-delta20|nitric oxide synthase 3 transcript variant eNOS-delta20-21|nitric oxide synthase 3 transcript variant eNOS-delta21|nitric oxide synthase, endothelial
Swissprots Q14251 Q6GSL5 A8KA63 Q14434 A0S0A8 B2RCQ1 P29474 E9PFR2 Q13662 Q9UDC6 A0S0A7 Q548C1
Accessions AAA36365 AAA36373 AAA36374 AAB87083 AAK71989 AAL07497 AAM74944 ABY87544 BAA05652 CAA53950 CDI44688 EAL24494 EAW54069 P29474 AF400594 AAK83389 AI082109 AK223636 BAD97356 AK225827 AK292928 BAF85617 AK300390 BAH13275 AK302686 BAH13779 AK315213 BAG37648 BC063294 AAH63294 BC069465 AAH69465 BU731828 CB987955 DA859819 DQ256129 ABB79838 DQ256130 ABB79839 DQ256131 ABB79840 HQ257992 ADR82746 JX853577 AFX88320 JX853578 AFX88321 JX853579 AFX88322 M93718 AAA36364 M95296 AAA36372 S80791 AAD14336 XM_006716002 XP_006716065 NM_000603 NP_000594 NM_001160109 NP_001153581 NM_001160110 NP_001153582 NM_001160111 NP_001153583
Function Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Subcellular Location Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
Tissue Specificity Platelets, placenta, liver and kidney. {ECO:0000269|PubMed:7515611}.
Top Pathways Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Oxytocin signaling pathway, Estrogen signaling pathway, PI3K-Akt signaling pathway

NOS3 CRISPR/Cas9 KO Plasmid (h) - sc-400127 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOS3 HDR Plasmid (h) - sc-400127-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOS3 Double Nickase Plasmid (h) - sc-400127-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOS3 Double Nickase Plasmid (h2) - sc-400127-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOS3 CRISPR Activation Plasmid (h) - sc-400127-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOS3 CRISPR Activation Plasmid (h2) - sc-400127-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOS3 Lentiviral Activation Particles (h) - sc-400127-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOS3 Lentiviral Activation Particles (h2) - sc-400127-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NOS3 siRNA (h) - sc-36093 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOS3 shRNA Plasmid (h) - sc-36093-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NOS3 shRNA (h) Lentiviral Particles - sc-36093-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN1360 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1360 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03636 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03636

NOS3 siRNA (Human) - CRH3219 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human NOS3 siRNA - orb263721 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NOS3 shRNA Plasmid (Human) - CHH3219 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NOS3 miRNA 3'UTR clone - MiUTR3H-01545 from Creative biogene

Species Reactivities Human

NOS3 miRNA 3'UTR clone - MiUTR3H-01546 from Creative biogene

Species Reactivities Human

NOS3 miRNA 3'UTR clone - MiUTR3H-01547 from Creative biogene

Species Reactivities Human

NOS3 miRNA 3'UTR clone - MiUTR3H-01548 from Creative biogene

Species Reactivities Human
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