| Gene Symbol | NOS3 |
|---|---|
| Entrez Gene | 4846 |
| Alt Symbol | ECNOS, eNOS |
| Species | Human |
| Gene Type | protein-coding |
| Description | nitric oxide synthase 3 (endothelial cell) |
| Other Description | EC-NOS|NOS type III|NOSIII|cNOS|constitutive NOS|endothelial NOS|nitric oxide synthase 3 transcript variant eNOS-delta20|nitric oxide synthase 3 transcript variant eNOS-delta20-21|nitric oxide synthase 3 transcript variant eNOS-delta21|nitric oxide synthase, endothelial |
| Swissprots | Q14251 Q6GSL5 A8KA63 Q14434 A0S0A8 B2RCQ1 P29474 E9PFR2 Q13662 Q9UDC6 A0S0A7 Q548C1 |
| Accessions | AAA36365 AAA36373 AAA36374 AAB87083 AAK71989 AAL07497 AAM74944 ABY87544 BAA05652 CAA53950 CDI44688 EAL24494 EAW54069 P29474 AF400594 AAK83389 AI082109 AK223636 BAD97356 AK225827 AK292928 BAF85617 AK300390 BAH13275 AK302686 BAH13779 AK315213 BAG37648 BC063294 AAH63294 BC069465 AAH69465 BU731828 CB987955 DA859819 DQ256129 ABB79838 DQ256130 ABB79839 DQ256131 ABB79840 HQ257992 ADR82746 JX853577 AFX88320 JX853578 AFX88321 JX853579 AFX88322 M93718 AAA36364 M95296 AAA36372 S80791 AAD14336 XM_006716002 XP_006716065 NM_000603 NP_000594 NM_001160109 NP_001153581 NM_001160110 NP_001153582 NM_001160111 NP_001153583 |
| Function | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. |
| Subcellular Location | Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity. |
| Tissue Specificity | Platelets, placenta, liver and kidney. {ECO:0000269|PubMed:7515611}. |
| Top Pathways | Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Oxytocin signaling pathway, Estrogen signaling pathway, PI3K-Akt signaling pathway |