MAPK14

Gene Symbol MAPK14
Entrez Gene 1432
Alt Symbol CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase 14
Other Description CSAID-binding protein|Csaids binding protein|MAP kinase 14|MAP kinase Mxi2|MAP kinase p38 alpha|MAX-interacting protein 2|cytokine suppressive anti-inflammatory drug binding protein|cytokine suppressive anti-inflammatory drug-binding protein|mitogen-activated protein kinase p38 alpha|p38 MAP kinase|p38 mitogen activated protein kinase|p38alpha Exip|stress-activated protein kinase 2A
Swissprots Q8TDX0 Q16539 O60776 A8K6P4 B5TY32 A6ZJ92 B0LPH0 Q13083 Q14084
Accessions AAC50329 ABY87549 AGC09599 EAX03867 EAX03868 EAX03869 EAX03870 EAX03871 EAX03872 EAX03873 Q16539 AB074150 BAB85654 AF100544 AAF36770 AK291709 BAF84398 AK303414 BAG64467 BC000092 AAH00092 BC031574 AAH31574 BT006933 AAP35579 CR536505 CAG38743 DA438432 FJ032367 ACI00233 FJ032368 ACI00234 L35263 AAA57455 L35264 AAA57456 Z25432 CAA80919 XM_006714998 XP_006715061 XM_011514310 XP_011512612 XM_011514311 XP_011512613 XR_926065 XR_926067 XR_926068 NM_001315 NP_001306 NM_139012 NP_620581 NM_139013 NP_620582 NM_139014 NP_620583
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mito
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
Top Pathways VEGF signaling pathway, Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Retrograde endocannabinoid signaling, Proteoglycans in cancer

Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP ® Rabbit mAb (Alexa Fluor ® 555 Conjugate) - 9836 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D3F9
Immunofluorescent analysis of HeLa cells, untreated (left) or UV-treated (right), using Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) (red) and β-Tubulin (9F3) Rabbit mAb (Alexa Fluor® 488 Conjugate) #3623 (green).

Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP ® Rabbit mAb (Alexa Fluor ® 594 Conjugate) - 8632 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D3F9
Immunofluorescent analysis of HeLa cells, untreated (left) or UV-treated (right) using Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP ® Rabbit mAb (Alexa Fluor ® 594 Conjugate) (red). Actin filaments were labeled with Alexa Fluor ® 488 phalloidin (green).

Phospho-p38 MAPK (Thr180/Tyr182) (3D7) Rabbit mAb (PE Conjugate) - 6908 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 3D7
Flow cytometric analysis of THP-1 cells, untreated (blue) or anisomycin-treated (green), using Phospho-p38 MAPK (Thr180/Tyr182) (3D7) Rabbit mAb (PE Conjugate).

Phospho-p38 MAPK (Thr180/Tyr182) (28B10) Mouse mAb (Alexa Fluor ® 488 Conjugate) - 4551 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone 28B10
Flow cytometric analysis of THP-1 cells, untreated (blue) or anisomycin-treated (green), using Phospho-p38 MAPK (Thr180/Tyr182) (28B10) Mouse mAb (Alexa Fluor ® 488 Conjugate) compared to a nonspecific control antibody (red).

Phospho-p38 MAPK (Thr180/Tyr182) (3D7) Rabbit mAb (Biotinylated) - 4092 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 3D7
Western blot analysis of p38 MAPK Control Cell Extracts #9213, untreated or anisomycin-treated, using Phospho-p38 MAPK (Thr180/Tyr182) (3D7) Rabbit mAb (Biotinylated).

Phospho-p38 MAPK (Thr180/Tyr182) (28B10) Mouse mAb (Alexa Fluor ® 647 Conjugate) - 4552 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone 28B10
Flow cytometric analysis of THP-1 cells, untreated (blue) or treated with Anisomycin (25ug/ml, 30 min; green) using Phospho-p38 MAPK (Thr180/Tyr182) (28B10) Mouse mAb (Alexa Fluor® 647 Conjugate) (solid lines) or concentration-matched Mouse (MOPC-21) mAb IgG1 Isotype Control (Alexa Fluor ® 647 Conjugate) #4843 (dashed lines).

p38 MAPK (D13E1) XP ® Rabbit mAb (HRP Conjugate) - 14451 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D13E1
Western blot analysis of extracts from HeLa and COS-7 cells using p38 MAPK (D13E1) XP ® Rabbit mAb (HRP Conjugate).

p38 MAPK (D13E1) XP ® Rabbit mAb (Biotinylated) - 2387 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D13E1
Western blot analysis of extracts from HeLa and NIH/3T3 cells using p38 MAPK (D13E1) XP ® Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for detection.

p38α MAPK (5F11) Mouse mAb (Alexa Fluor® 647 Conjugate) - 4555 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone 5F11

p38α MAPK (5F11) Mouse mAb (Alexa Fluor® 488 Conjugate) - 4556 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone 5F11

Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP ® Rabbit mAb - 4511 from Cell Signaling Technology

Prices $119.00, $318.00, $750.00
Sizes 20 µl (2 western blots), 200 µl (20 western blots), 600 µl (60 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3F9
Western blot analysis of extracts from COS and 293 cells, untreated or UV-treated, using Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP ® Rabbit mAb (upper) or p38 MAPK Antibody #9212 (lower).

Phospho-p38 MAPK (Thr180/Tyr182) (28B10) Mouse mAb - 9216 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (20 western blots), 300 µl (60 western blots)
Host Mouse
Clonality Monoclonal
Clone 28B10
Western blot analysis of extracts from HeLa and NIH/3T3 cells, untreated or treated as indicated, using Phospho-p38 MAPK (Thr180/Tyr182) (28B10) Mouse mAb (upper) or p38 MAPK Antibody #9212 (lower).

Phospho-p38 MAPK (Thr180/Tyr182) (12F8) Rabbit mAb - 4631 from Cell Signaling Technology

Prices $307.00, $719.00
Sizes 200 µl (20 western blots), 600 µl (60 western blots)
Host Rabbit
Clonality Monoclonal
Clone 12F8
Western blot analysis of extracts from Jurkat, NIH/3T3 and PC12 cells, untreated or treated as indicated, using Phospho-p38 MAPK (Thr180/Tyr182) (12F8) Rabbit mAb.

Phospho-p38 MAPK (Thr180/Tyr182) (3D7) Rabbit mAb - 9215 from Cell Signaling Technology

Prices $307.00, $719.00
Sizes 200 µl (20 western blots), 600 µl (60 western blots)
Host Rabbit
Clonality Monoclonal
Clone 3D7
Specificity of Phospho-Erk1/2, Phospho-p38 MAPK and Phospho-SAPK/JNK Rabbit mAb: Western blot analysis of extracts from NIH/3T3 cells treated with PDGF and UV, using Phospho-p38 MAPK Rabbit mAb #9215, Phospho-SAPK/JNK Rabbit mAb and Phospho-Erk1/2 Rabbit mAb.

Phospho-p38 MAPK (Thr180/Tyr182) Antibody - 9211 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 200 µl (20 western blots), 600 µl (60 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from C6 cells, untreated or anisomycin-treated, and NIH/3T3 cells, untreated or UV-treated, using Phospho-p38 MAPK (Thr180/Tyr182) Antibody (upper) or p38 MAPK Antibody #9212 (lower).

p38 MAPK (D13E1) XP ® Rabbit mAb - 8690 from Cell Signaling Technology

Prices $109.00, $277.00, $658.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone D13E1
Western blot analysis of extracts from various cell lines using p38 MAPK (D13E1) XP ® Rabbit mAb.

p38α MAPK (7D6) Rabbit mAb - 2371 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 7D6
Western blot analysis of extracts from HeLa, NIH/3T3 and C6 cells, using p38α MAPK (7D6) Rabbit mAb.

p38α MAPK (5F11) Mouse mAb - 9217 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (20 western blots)
Host Mouse
Clonality Monoclonal
Clone 5F11
Western blot analysis of extracts from HeLa and C6 cells using p38α MAPK (5F11) Mouse mAb.

p38α MAPK (L53F8) Mouse mAb - 9228 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L53F8
Western blot analysis of extracts from HeLa, NIH/3T3 and C6 cells, using p38α MAPK (L53F8) Mouse mAb.

p38α MAPK Antibody - 9218 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3, PC12 and COS cells, using p38α MAPK Antibody.

p38 MAPK Antibody - 9212 from Cell Signaling Technology

Prices $246.00, $596.00
Sizes 200 µl (20 western blots), 600 µl (60 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® p38 MAPK siRNA I #6564 (+) or SignalSilence ® p38 MAPK siRNA II (+), using p38 MAPK Antibody #9212 and α-Tubulin (11H10) Rabbit mAb #2125. The p38 MAPK antibody confirms silencing of p38 MAPK expression while the α-Tubulin (11H10) Rabbit mAb is used to control for loading and specificity of p38 MAPK siRNA.

phospho-p38MAPK (Thr180/Tyr182) (28B10) Mouse mAb - 5140 from Cell Signaling Technology

Host Mouse
Clonality Monoclonal
Clone 28B10

p38α (9F12) - sc-81621 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p38α (9F12): sc-81621. Western blot analysis of p38α expression in non-transfected 293T: sc-117752 (A), human p38α transfected 293T: sc-114258 (B) and Jurkat (C) whole cell lysates.

p38α (D-5) - sc-398305 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p38α (D-5): sc-398305. Western blot analysis of p38α expression in NIH/3T3 (A), KNRK (B), Jurkat (C) and HL-60 (D) whole cell lysates.

p38α (A1F7) - sc-33688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p38α (A1F7): sc-33688. Western blot analysis of human recombinant p38α.
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