MAPK14

Gene Symbol MAPK14
Entrez Gene 1432
Alt Symbol CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase 14
Other Description CSAID-binding protein|Csaids binding protein|MAP kinase 14|MAP kinase Mxi2|MAP kinase p38 alpha|MAX-interacting protein 2|cytokine suppressive anti-inflammatory drug binding protein|cytokine suppressive anti-inflammatory drug-binding protein|mitogen-activated protein kinase p38 alpha|p38 MAP kinase|p38 mitogen activated protein kinase|p38alpha Exip|stress-activated protein kinase 2A
Swissprots Q8TDX0 Q16539 O60776 A8K6P4 B5TY32 A6ZJ92 B0LPH0 Q13083 Q14084
Accessions AAC50329 ABY87549 AGC09599 EAX03867 EAX03868 EAX03869 EAX03870 EAX03871 EAX03872 EAX03873 Q16539 AB074150 BAB85654 AF100544 AAF36770 AK291709 BAF84398 AK303414 BAG64467 BC000092 AAH00092 BC031574 AAH31574 BT006933 AAP35579 CR536505 CAG38743 DA438432 FJ032367 ACI00233 FJ032368 ACI00234 L35263 AAA57455 L35264 AAA57456 Z25432 CAA80919 XM_006714998 XP_006715061 XM_011514310 XP_011512612 XM_011514311 XP_011512613 XR_926065 XR_926067 XR_926068 NM_001315 NP_001306 NM_139012 NP_620581 NM_139013 NP_620582 NM_139014 NP_620583
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mito
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
Top Pathways VEGF signaling pathway, Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Retrograde endocannabinoid signaling, Proteoglycans in cancer

PathScan ® Phospho-p38 MAPK (Thr180/Tyr182) Sandwich ELISA Kit - 7946 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

PathScan ® Phospho-p38α MAPK (Thr180/Tyr182) Sandwich ELISA Antibody Pair - 7221 from Cell Signaling Technology

Category Antibody Pair

PathScan® Phospho-p38α MAPK (Thr180/Tyr182) Sandwich ELISA Kit - 7140 from Cell Signaling Technology

Category ELISA Kit

p38 MAP Kinase Assay Kit (Nonradioactive) - 9820 from Cell Signaling Technology

Category Assay Kit
Prices $379.00
Sizes 40 assays
Analysis of p38 MAP Kinase activity of UV-treated NIH-3T3 cells by western blot using Phospho-ATF-2 (Thr71) Antibody. Cell extracts were incubated overnight with Immobilized p38 MAPK (Thr180/Tyr182) mAb. Kinase reaction was performed in the presence of 100 µM of cold ATP and 1 µg of ATF-2 fusion protein. Phosphorylation of ATF-2 at Thr71 was measured by western blot using Phospho-ATF-2 (Thr71) Antibody.

p38 MAPK alpha (pT180/pY182) + total p38 MAPK alpha ELISA Kit - ab126453 from Abcam

Category ELISA Kit
Prices $499.00
Sizes 1 x 96 tests
HeLa cells were treated with Anisomycin at 37°C for 10 min. Solubilize cells at 4 x 107 cells/ml in Cell Lysate Buffer. Serial dilutions of lysates were analyzed in this ELISA.

p38 MAPK alpha (pT180/pY182) ELISA Kit - ab126452 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
HeLa cells were treated with Anisomycin at 37°C for 10 min. Solubilize cells at 4 x 107 cells/ml in Cell Lysate Buffer. Serial dilutions of lysates were analyzed in this ELISA.

p38 MAPK alpha (pT180/Y182) + Total SimpleStep ELISA™ Kit - ab176664 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Example of a typical p38 MAPKα (pT180/Y182) and p38 MAPKα (Total) cell lysate dilution series. Background-subtracted data values (mean +/- SD) are graphed.

p38 MAPK alpha (pT180/Y182) PhosphoTracer ELISA Kit - ab119638 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
Sensitivity 0.1 ng/ml
Range 0.1 ng/ml - 250 ng/ml
Using Western blot, a significant stimulation of p38 MAPKalpha phosphorylation at Thr180/Tyr182 is detected in HEK293 cells treated with anisomycin for 30 minutes (+) compared with untreated cells (-), while no change in total p38 MAPKalpha levels is observed.

p38 MAPK alpha (pT180/Y182) SimpleStep ELISA™ Kit - ab176649 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity < 1 ng/ml
Range 1 ng/ml - 100 ng/ml
Example of a typical p38 MAPKα (pT180/Y182) cell lysate dilution series. Background-subtracted data values (mean +/- SD) are graphed.

p38 MAPK alpha (Thr180/Tyr182) In-Cell ELISA Kit - ab126425 from Abcam

Category ELISA Kit
Prices $489.00
Sizes 1 x 96 tests
HeLa cells were stimulated by different concentrations of anisomycin for 15 minutes at 37°C. 
As shown, using the p38 MAPKalpha assay kits, a significant stimulation of p38 MAPKalpha phosphorylation at Thr180/Tyr182 is detected in HEK293 cells treated with anisomycin for 30 minutes compared with untreated cells, while no change in total p38 MAPKalpha levels is observed.

p38 MAPK alpha Total PhosphoTracer ELISA Kit - ab119639 from Abcam

Category ELISA Kit
Sensitivity 1 ng/ml
Range 1 ng/ml - 250 ng/ml
Using Western blot, a significant stimulation of p38 MAPKalpha phosphorylation at Thr180/Tyr182 is detected in HEK293 cells treated with anisomycin for 30 minutes (+) compared with untreated cells (-), while no change in total p38 MAPKalpha levels is observed.

p38 MAPK alpha Total SimpleStep ELISA™ Kit - ab176650 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity < 0.1 ng/ml
Range 0.5 ng/ml - 50 ng/ml
Example of a typical p38 MAPKα cell lysate dilution series. Raw data values are shown in the table. Background-subtracted data values (mean +/- SD) are graphed.

Human MAPK14 / p38 ELISA Kit (Sandwich ELISA) - LS-F4477 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 0.54 ng/ml
Range 1.56 - 100 ng/ml

Mouse/Human Phospho-MAPK14 / p38 (Thr180, Tyr182) ELISA Kit - LS-F545 from LifeSpan Bioscience

Category ELISA Kit
Prices $540.00, $950.00, $2,180.00
Sizes 1 plate, 2 plate, 5 plate

Mouse/Human/Rat Phospho-MAPK14 / p38 (Tyr322) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1299 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-MAPK14 / p38 (Thr179, Tyr181) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1300 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-MAPK14 / p38 (Thr180) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1587 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat Phospho-MAPK14 / p38 (Tyr182) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1588 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human/Rat MAPK14 / p38 ELISA Kit (Cell-Based ELISA) - LS-F2206 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Rat MAPK14 / p38 ELISA Kit (Sandwich ELISA) - LS-F9028 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 0.43 ng/ml
Range 1.25 - 80 ng/ml

Human MAPK14 / p38 ELISA Kit (Sandwich ELISA) - LS-F12046 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.156 - 10 ng/ml

Phosphotyrosine MAPK14 / Mitogen-activated Protein Kinase 14 ELISA Kit - RAB0983 from Sigma-Aldrich

Category ELISA Kit
Prices $637.00
Sizes 1 kt

Phospho-p38 α (pThr180 / pTyr182) and pan-p38 ELISA Kit - RAB0345 from Sigma-Aldrich

Category ELISA Kit
Prices $570.00
Sizes 1 kt
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