MAPK14
| Gene Symbol | MAPK14 |
|---|---|
| Entrez Gene | 1432 |
| Alt Symbol | CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 14 |
| Other Description | CSAID-binding protein|Csaids binding protein|MAP kinase 14|MAP kinase Mxi2|MAP kinase p38 alpha|MAX-interacting protein 2|cytokine suppressive anti-inflammatory drug binding protein|cytokine suppressive anti-inflammatory drug-binding protein|mitogen-activated protein kinase p38 alpha|p38 MAP kinase|p38 mitogen activated protein kinase|p38alpha Exip|stress-activated protein kinase 2A |
| Swissprots | Q8TDX0 Q16539 O60776 A8K6P4 B5TY32 A6ZJ92 B0LPH0 Q13083 Q14084 |
| Accessions | AAC50329 ABY87549 AGC09599 EAX03867 EAX03868 EAX03869 EAX03870 EAX03871 EAX03872 EAX03873 Q16539 AB074150 BAB85654 AF100544 AAF36770 AK291709 BAF84398 AK303414 BAG64467 BC000092 AAH00092 BC031574 AAH31574 BT006933 AAP35579 CR536505 CAG38743 DA438432 FJ032367 ACI00233 FJ032368 ACI00234 L35263 AAA57455 L35264 AAA57456 Z25432 CAA80919 XM_006714998 XP_006715061 XM_011514310 XP_011512612 XM_011514311 XP_011512613 XR_926065 XR_926067 XR_926068 NM_001315 NP_001306 NM_139012 NP_620581 NM_139013 NP_620582 NM_139014 NP_620583 |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mito |
| Subcellular Location | Cytoplasm. Nucleus. |
| Tissue Specificity | Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney. |
| Top Pathways | VEGF signaling pathway, Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Retrograde endocannabinoid signaling, Proteoglycans in cancer |
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