MAPK14

Gene Symbol	MAPK14
Entrez Gene	1432
Alt Symbol	CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 14
Other Description	CSAID-binding protein|Csaids binding protein|MAP kinase 14|MAP kinase Mxi2|MAP kinase p38 alpha|MAX-interacting protein 2|cytokine suppressive anti-inflammatory drug binding protein|cytokine suppressive anti-inflammatory drug-binding protein|mitogen-activated protein kinase p38 alpha|p38 MAP kinase|p38 mitogen activated protein kinase|p38alpha Exip|stress-activated protein kinase 2A
Swissprots	Q8TDX0 Q16539 O60776 A8K6P4 B5TY32 A6ZJ92 B0LPH0 Q13083 Q14084
Accessions	AAC50329 ABY87549 AGC09599 EAX03867 EAX03868 EAX03869 EAX03870 EAX03871 EAX03872 EAX03873 Q16539 AB074150 BAB85654 AF100544 AAF36770 AK291709 BAF84398 AK303414 BAG64467 BC000092 AAH00092 BC031574 AAH31574 BT006933 AAP35579 CR536505 CAG38743 DA438432 FJ032367 ACI00233 FJ032368 ACI00234 L35263 AAA57455 L35264 AAA57456 Z25432 CAA80919 XM_006714998 XP_006715061 XM_011514310 XP_011512612 XM_011514311 XP_011512613 XR_926065 XR_926067 XR_926068 NM_001315 NP_001306 NM_139012 NP_620581 NM_139013 NP_620582 NM_139014 NP_620583
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mito
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
Top Pathways	VEGF signaling pathway, Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Retrograde endocannabinoid signaling, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® p38α MAPK siRNA II - 6277 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® p38 MAPK siRNA II - 6243 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® p38α MAPK siRNA I - 6269 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® p38 MAPK siRNA I - 6564 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence® Pool p38 MAPK siRNA - 6386 from Cell Signaling Technology Category siRNA Species Reactivities Human

p38α CRISPR/Cas9 KO Plasmid (h) - sc-400057 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p38α HDR Plasmid (h) - sc-400057-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38α Double Nickase Plasmid (h) - sc-400057-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38α Double Nickase Plasmid (h2) - sc-400057-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38α CRISPR Activation Plasmid (h) - sc-400057-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p38α CRISPR Activation Plasmid (h2) - sc-400057-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p38α Lentiviral Activation Particles (h) - sc-400057-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38α Lentiviral Activation Particles (h2) - sc-400057-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38α siRNA (h) - sc-29433 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38α shRNA Plasmid (h) - sc-29433-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38α shRNA (h) Lentiviral Particles - sc-29433-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38α siRNA (h2) - sc-44216 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38α shRNA Plasmid (h2) - sc-44216-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38α shRNA (h2) Lentiviral Particles - sc-44216-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38 RNAi - H00001432-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

p38 RNAi - H00001432-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

p38 RNAi - H00001432-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU081441 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1202 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1201 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

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