| Gene Symbol |
Cdk5r1
|
| Entrez Gene |
116671
|
| Alt Symbol |
Cdk5r, p35
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
|
| Other Description |
CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|p23|tau protein kinase II 23 kDa subunit
|
| Swissprots |
Q62938 P61810
|
| Accessions |
EDM05425 P61810 U50707 AAC52611 NM_053891 NP_446343
|
| Function |
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
|
| Tissue Specificity |
Brain and neuron specific.
|
| Top Pathways |
Alzheimer's disease, Cocaine addiction
|
