| Gene Symbol | Cdk5r1 |
|---|---|
| Entrez Gene | 116671 |
| Alt Symbol | Cdk5r, p35 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
| Other Description | CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|p23|tau protein kinase II 23 kDa subunit |
| Swissprots | Q62938 P61810 |
| Accessions | EDM05425 P61810 U50707 AAC52611 NM_053891 NP_446343 |
| Function | p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). {ECO:0000250}. |
| Subcellular Location | Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. |
| Tissue Specificity | Brain and neuron specific. |
| Top Pathways | Alzheimer's disease, Cocaine addiction |
Recombinant Interleukin 12A (IL12A) - RPA059Ra01 from Cloud-clone
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Recombinant Rat Cyclin-dependent kinase 5 activator 1(Cdk5r1) - CSB-YP005069RA CSB-EP005069RA CSB-BP005069RA CSB-MP005069RA from Cusabio
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Recombinant Rat CDK5R1 Protein - CDK5R1-1306R from Creative Biomart
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Cyclin-dependent kinase 5 activator 1 (Cdk5r1), Recombinant Protein - MBS952436 from MyBioSource
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