Gene Symbol | Cdk5r1 |
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Entrez Gene | 116671 |
Alt Symbol | Cdk5r, p35 |
Species | Rat |
Gene Type | protein-coding |
Description | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
Other Description | CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|p23|tau protein kinase II 23 kDa subunit |
Swissprots | Q62938 P61810 |
Accessions | EDM05425 P61810 U50707 AAC52611 NM_053891 NP_446343 |
Function | p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). {ECO:0000250}. |
Subcellular Location | Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. |
Tissue Specificity | Brain and neuron specific. |
Top Pathways | Alzheimer's disease, Cocaine addiction |
Cyclin-dependent kinase 5 activator 1 (CDK5R1), Rat, ELISA Kit - E02C1557 from ARP American Research Products
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Ficolin-2 (FCN2), Rat, ELISA Kit - CSB-EL008551RA from ARP American Research Products
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Interleukin 12A (IL12A), Rat, ELISA Kit - SEA059Ra from ARP American Research Products
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ELISA Kit for Interleukin 12A (IL12A) - SEA059Ra from Cloud-clone
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Rat Cyclin-dependent kinase 5 activator 1 ELISA Kit - abx256533 from Abbexa
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Rat Cyclin-dependent kinase 5 activator 1 ELISA Kit - EKE55381 from Biomatik
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Cdk5r1 - EKR1116 from Nordic BioSite
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Rat Cdk5r1 ELISA Kit - E078085 from Biobool
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Cdk5r1 ELISA Kit (Rat) (OKEH04799) - OKEH04799 from Aviva Systems Biology
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Rat Cyclin-dependent kinase 5 activator 1 ELISA Kit - EK3637 from Signalway Antibody
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Cyclin-dependent kinase 5 activator 1, ELISA Kit - MBS9427471 from MyBioSource
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Cyclin-dependent kinase 5 activator 1, ELISA Kit - MBS2884327 from MyBioSource
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