| Gene Symbol | Cdk5r1 |
|---|---|
| Entrez Gene | 116671 |
| Alt Symbol | Cdk5r, p35 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
| Other Description | CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|p23|tau protein kinase II 23 kDa subunit |
| Swissprots | Q62938 P61810 |
| Accessions | EDM05425 P61810 U50707 AAC52611 NM_053891 NP_446343 |
| Function | p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). {ECO:0000250}. |
| Subcellular Location | Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. |
| Tissue Specificity | Brain and neuron specific. |
| Top Pathways | Alzheimer's disease, Cocaine addiction |
CompoZr® Knockout ZFN Kit - CKOZFN51856 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND51856 from Sigma-Aldrich
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CDK5R1 siRNA (Rat) - CRR2982 from Cohesion Biosciences
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CDK5R1 - MBS8222498 from MyBioSource
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shRNA set against Rat CDK5R1 (NM_053891.1) - SHH260645 from Creative biogene
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shRNA set against Rat Cdk5r1(NM_053891.1) - SHG164683 from Creative biogene
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Rat CDK5R1 siRNA - orb297831 from Biorbyt
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CDK5R1 shRNA Plasmid (Rat) - CHR2982 from Cohesion Biosciences
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CDK5R1 miRNA 3'UTR clone - MiUTR1R-00908 from Creative biogene
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