GZMB

Gene Symbol	GZMB
Entrez Gene	3002
Alt Symbol	CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Species	Human
Gene Type	protein-coding
Description	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Other Description	C11|CTLA-1|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|fragmentin-2|granzyme B|human lymphocyte protein
Swissprots	Q9UCC1 Q8N1D2 P10144
Accessions	AAA67124 AAA75490 AAB59528 EAW66002 EAW66003 P10144 AY232654 AAP70244 AY232655 AAP70245 AY232656 AAP70246 AY372494 AAR23323 BC030195 AAH30195 BX283601 CB528665 EU176524 ABW03325 J03189 AAA36603 J04071 AAA52118 M17016 AAA36627 XM_011536685 XP_011534987 NM_004131 NP_004122
Function	This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location	Cytoplasmic granule {ECO:0000269|PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Top Pathways	Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Granzyme B (CTLA-1) Human ELISA Kit - ab46142 from Abcam Category ELISA Kit Prices $489.00, $734.00 Sizes 1 x 96 tests, 2 x 96 tests Sensitivity < 20 pg/ml Range 31.25 pg/ml - 1000 pg/ml

Granzyme B Human Elispot Kit - ab46617 from Abcam Category ELISA Kit Prices $937.00, $1,563.00 Sizes 5 x 96 tests, 10 x 96 tests

Granzyme B Human Elispot Kit - ab62922 from Abcam Category ELISA Kit Prices $339.00, $937.00 Sizes 1 x 96 tests, 5 x 96 tests

Granzyme B Human Elispot Kit (Reagents for 10 x 96 tests, without plates) - ab46634 from Abcam Category ELISA Kit Prices $1,021.00 Sizes 10 x 96 tests

Granzyme B Human Elispot Kit (Reagents for 15 x 96 tests, without plates) - ab48705 from Abcam Category ELISA Kit Prices $1,359.00 Sizes 15 x 96 tests

Granzyme B Human Elispot Kit (Reagents for 20 x 96 tests, without plates) - ab48706 from Abcam Category ELISA Kit Prices $1,614.00 Sizes 20 x 96 tests

Granzyme B Human Elispot Kit (without plates) - ab46581 from Abcam Category ELISA Kit Prices $729.00, $1,021.00, $1,359.00, $1,614.00 Sizes 5 x 96 tests, 10 x 96 tests, 15 x 96 tests, 20 x 96 tests

Granzyme B Activity Assay Kit (Fluorometric) - ab157403 from Abcam Category Cellular Assay Prices $500.00 Sizes 100 tests

Granzyme B Inhibitor Screening Assay Kit - ab157405 from Abcam Category Cellular Assay Prices $577.00 Sizes 100 tests

Human GZMB / Granzyme B ELISA Kit (Sandwich ELISA) - LS-F2832 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 40-5000 pg/ml

Human GZMB / Granzyme B ELISA Kit (Sandwich ELISA) - LS-F4301 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 3 pg/ml Range 40-5000 pg/ml

Mouse GZMB / Granzyme B ELISA Kit (Sandwich ELISA) - LS-F4303 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 6.4 pg/ml Range 40-5000 pg/ml

Rat GZMB / Granzyme B ELISA Kit (Sandwich ELISA) - LS-F4302 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 6.3 pg/ml Range 40-5000 pg/ml

Mouse GZMB / Granzyme B ELISA Kit (Sandwich ELISA) - LS-F663 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 40-5000 pg/ml

Mouse/Human/Rat GZMB / Granzyme B ELISA Kit (Cell-Based ELISA) - LS-F2025 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 40-5000 pg/ml

Mouse GZMB / Granzyme B ELISA Kit - LS-F496 from LifeSpan Bioscience Category ELISA Kit Prices $600.00, $1,100.00, $2,520.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 12 pg/ml

Human GZMB / Granzyme B ELISA Kit (Sandwich ELISA) - LS-F11574 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 Range 40-5000 pg/ml

Mouse Granzyme B DuoSet ELISA - DY1865 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human Granzyme B ELISA kit - 55R-IB49682 from Fitzgerald Category ELISA Kit Prices $825.00 Sizes 96 wells

Human Granzymes B ELISA kit - 55R-2068 from Fitzgerald Category ELISA Kit Prices $505.00 Sizes 96 tests

Human Granzyme B ELISA Kit - abx151730 from Abbexa Category ELISA Kit Sensitivity 2.6 pg/ml Range 7.813 pg/ml - 500 pg/ml

Human Granzyme B ELISA Kit - abx056182 from Abbexa Category ELISA Kit

Granzyme B (GZMB), Human, ELISA Kit - SEA600Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 3.1pg/mL Range 7.8-500pg/mL

Granzyme B, GZMB, Human, ELISA Kit - E0600h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 15.6-1000 pg/mL

Granzyme B, Human, ELISA - IB49682 from ARP American Research Products Category ELISA Kit Prices $802.00 Sizes 96 t

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