GZMB

Gene Symbol GZMB
Entrez Gene 3002
Alt Symbol CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Species Human
Gene Type protein-coding
Description granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Other Description C11|CTLA-1|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|fragmentin-2|granzyme B|human lymphocyte protein
Swissprots Q9UCC1 Q8N1D2 P10144
Accessions AAA67124 AAA75490 AAB59528 EAW66002 EAW66003 P10144 AY232654 AAP70244 AY232655 AAP70245 AY232656 AAP70246 AY372494 AAR23323 BC030195 AAH30195 BX283601 CB528665 EU176524 ABW03325 J03189 AAA36603 J04071 AAA52118 M17016 AAA36627 XM_011536685 XP_011534987 NM_004131 NP_004122
Function This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location Cytoplasmic granule {ECO:0000269|PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Top Pathways Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

granzyme B CRISPR/Cas9 KO Plasmid (h) - sc-401469 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme B HDR Plasmid (h) - sc-401469-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme B Double Nickase Plasmid (h) - sc-401469-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme B Double Nickase Plasmid (h2) - sc-401469-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme B CRISPR Activation Plasmid (h) - sc-401469-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme B CRISPR Activation Plasmid (h2) - sc-401469-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme B Lentiviral Activation Particles (h) - sc-401469-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme B Lentiviral Activation Particles (h2) - sc-401469-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

granzyme B siRNA (h) - sc-35507 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

granzyme B shRNA Plasmid (h) - sc-35507-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

granzyme B shRNA (h) Lentiviral Particles - sc-35507-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Granzyme B RNAi - H00003002-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU106641 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9827 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9827 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GZMB siRNA (Human) - CRH2037 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GZMB - MBS8230997 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GZMB (NM_004131.4) - SHH309650 from Creative biogene

Category siRNA
Species Reactivities Human

GZMB shRNA Plasmid (Human) - CHH2037 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GZMB miRNA 3'UTR clone - MiUTR3H-00608 from Creative biogene

Species Reactivities Human
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