GZMB

Gene Symbol GZMB
Entrez Gene 3002
Alt Symbol CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Species Human
Gene Type protein-coding
Description granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Other Description C11|CTLA-1|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|fragmentin-2|granzyme B|human lymphocyte protein
Swissprots Q9UCC1 Q8N1D2 P10144
Accessions AAA67124 AAA75490 AAB59528 EAW66002 EAW66003 P10144 AY232654 AAP70244 AY232655 AAP70245 AY232656 AAP70246 AY372494 AAR23323 BC030195 AAH30195 BX283601 CB528665 EU176524 ABW03325 J03189 AAA36603 J04071 AAA52118 M17016 AAA36627 XM_011536685 XP_011534987 NM_004131 NP_004122
Function This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location Cytoplasmic granule {ECO:0000269|PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Top Pathways Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

Human-GZMB-cDNA-Clone - DC06059 from Abgent, a WuXi AppTec company

Prices $333.45
Sizes 10 µg
Species Human
Accession BC030195

GZMB - MBS1273885 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC030195

Human GZMB ORF Clone(NM_004131.4) - CDCL165654 from Creative Biomart

Species Human
Accession NM_004131.4

Human GZMB Gene cDNA Clone (full-length ORF Clone) - HG13352-G from Sino Biological

Species Human
Accession BC030195
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