GZMB

Gene Symbol	GZMB
Entrez Gene	3002
Alt Symbol	CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Species	Human
Gene Type	protein-coding
Description	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Other Description	C11|CTLA-1|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|fragmentin-2|granzyme B|human lymphocyte protein
Swissprots	Q9UCC1 Q8N1D2 P10144
Accessions	AAA67124 AAA75490 AAB59528 EAW66002 EAW66003 P10144 AY232654 AAP70244 AY232655 AAP70245 AY232656 AAP70246 AY372494 AAR23323 BC030195 AAH30195 BX283601 CB528665 EU176524 ABW03325 J03189 AAA36603 J04071 AAA52118 M17016 AAA36627 XM_011536685 XP_011534987 NM_004131 NP_004122
Function	This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location	Cytoplasmic granule {ECO:0000269|PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Top Pathways	Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Granzyme B full length protein - ab180052 from Abcam Category Protein Prices $357.00 Sizes 20 µg Source HEK 293 cells Species Human

Active human Granzyme B full length protein - ab168093 from Abcam Category Protein Prices $1,598.00 Sizes 10 µg Source Native Species Human

Active mouse Granzyme B protein fragment - ab50114 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source Baculovirus infected High-5 cells Species Mouse

Human Granzyme B full length protein - ab158621 from Abcam Category Protein Source Wheat germ Species Human

Human Granzyme B full length protein - ab158622 from Abcam Category Protein Source Wheat germ Species Human

Human Granzyme B full length protein - ab202180 from Abcam Category Protein Source E. coli Species Human

Human Granzyme B peptide - ab73723 from Abcam Category Peptide

Human Granzyme B protein fragment - ab158623 from Abcam Category Protein Source Wheat germ Species Human

GZMB / Granzyme B Antibody Blocking Peptide - LS-E8301 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GZMB / Granzyme B Antibody Blocking Peptide - LS-E8302 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Granzyme B Partial Recombinant Protein - H00003002-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Granzyme B Protein - H00003002-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

IFN-gamma/Granzyme B Recombinant Protein - H00003002-P01 from Novus Biologicals Category Protein Species Human

GZMB-Antibody-C-term-Blocking-Peptide - BP6575b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GZMB-Antibody-N-term-Blocking-Peptide - BP6575a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Granzyme B, CF - 2906-SE-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly19-Tyr247, with a C-terminal 10-His tag

Human GZMB protein - orb244258 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human GZMB protein - orb245858 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

GZMB peptide - orb217385 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Drosophila

Granzyme B Blocking Peptide - 33R-10617 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Granzyme B protein - 30R-2408 from Fitzgerald Category Protein Prices $445.00 Sizes 5 µg Source Insect cells

GZMB protein (His tag) - 80R-4112 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Granzyme B/H Blocking Peptide - abx062716 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Pig

Granzyme B (GZMB) (21-247, His-tag) - AR51798PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Granzyme B (GZMB) (21-247, His-tag) - AR51798PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

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