| Gene Symbol | GZMB |
|---|---|
| Entrez Gene | 3002 |
| Alt Symbol | CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT |
| Species | Human |
| Gene Type | protein-coding |
| Description | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| Other Description | C11|CTLA-1|T-cell serine protease 1-3E|cathepsin G-like 1|cytotoxic T-lymphocyte proteinase 2|cytotoxic serine protease B|fragmentin 2|fragmentin-2|granzyme B|human lymphocyte protein |
| Swissprots | Q9UCC1 Q8N1D2 P10144 |
| Accessions | AAA67124 AAA75490 AAB59528 EAW66002 EAW66003 P10144 AY232654 AAP70244 AY232655 AAP70245 AY232656 AAP70246 AY372494 AAR23323 BC030195 AAH30195 BX283601 CB528665 EU176524 ABW03325 J03189 AAA36603 J04071 AAA52118 M17016 AAA36627 XM_011536685 XP_011534987 NM_004131 NP_004122 |
| Function | This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
| Subcellular Location | Cytoplasmic granule {ECO:0000269|PubMed:8258716}. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells. |
| Top Pathways | Natural killer cell mediated cytotoxicity, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Type I diabetes mellitus |