DHFR

Gene Symbol DHFR
Entrez Gene 1719
Alt Symbol DHFRP1, DYR
Species Human
Gene Type protein-coding
Description dihydrofolate reductase
Other Description -
Swissprots B4DDD2 P00374 Q6IRW8 Q14130
Accessions AAA58484 CAA25409 EAW95859 EAW95860 P00374 AA489055 AK293146 BAG56693 AK297302 BAG59770 AK308492 AK312642 BAG35526 BC000192 AAH00192 BC003584 AAH03584 BC009634 BC070280 AAH70280 BC071996 AAH71996 CB988944 DQ892816 ABM83742 DQ896062 ABM87061 EU145592 ABX57718 J00140 AAA58485 V00507 CAA23765 NM_000791 NP_000782 NM_001290354 NP_001277283 NM_001290357 NP_001277286 NR_110936
Function Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. {ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:21876188}.
Tissue Specificity Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain. {ECO:0000269|PubMed:21310276}.
Top Pathways Folate biosynthesis, One carbon pool by folate

DHFR-Over-expression-Lysate - LY11080a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag DHFR (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DHFR gene

DHFR 293T Cell Transient Overexpression Lysate(Denatured) - H00001719-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

DHFR 293 Cell Lysate - 400317 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Dihydrofolate Reductase/DHFR Overexpression Lysate (Denatured) - H00001719-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
DHFR transfected lysate.

Dihydrofolate Reductase/DHFR Overexpression Lysate (Native) - NBL1-09860 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Dihydrofolate reductase Overexpression Lysate (Adult Normal) [NBL1-09860] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dihydrofolate reductase.

DHFR (h2): 293T Lysate - sc-170387 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

DHFR Over-expression Lysate Product - GWB-81BA40 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human DHFR Knockdown Stable Cell Line - CSC-DC004265 from Creative biogene

Category Cell Line
Species Human
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