DHFR

Gene Symbol DHFR
Entrez Gene 1719
Alt Symbol DHFRP1, DYR
Species Human
Gene Type protein-coding
Description dihydrofolate reductase
Other Description -
Swissprots B4DDD2 P00374 Q6IRW8 Q14130
Accessions AAA58484 CAA25409 EAW95859 EAW95860 P00374 AA489055 AK293146 BAG56693 AK297302 BAG59770 AK308492 AK312642 BAG35526 BC000192 AAH00192 BC003584 AAH03584 BC009634 BC070280 AAH70280 BC071996 AAH71996 CB988944 DQ892816 ABM83742 DQ896062 ABM87061 EU145592 ABX57718 J00140 AAA58485 V00507 CAA23765 NM_000791 NP_000782 NM_001290354 NP_001277283 NM_001290357 NP_001277286 NR_110936
Function Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. {ECO:0000269|PubMed:12096917, ECO:0000269|PubMed:21876188}.
Tissue Specificity Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain. {ECO:0000269|PubMed:21310276}.
Top Pathways Folate biosynthesis, One carbon pool by folate

DHFR CRISPR/Cas9 KO Plasmid (h) - sc-417022 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHFR HDR Plasmid (h) - sc-417022-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHFR Double Nickase Plasmid (h) - sc-417022-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHFR Double Nickase Plasmid (h2) - sc-417022-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHFR CRISPR Activation Plasmid (h) - sc-417022-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHFR CRISPR Activation Plasmid (h2) - sc-417022-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHFR Lentiviral Activation Particles (h) - sc-417022-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHFR Lentiviral Activation Particles (h2) - sc-417022-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DHFR siRNA (h) - sc-37078 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DHFR shRNA Plasmid (h) - sc-37078-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DHFR shRNA (h) Lentiviral Particles - sc-37078-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dihydrofolate Reductase/DHFR RNAi - H00001719-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN1085 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1085 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DHFR siRNA (Human) - CRH1193 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DHFR - MBS827645 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DHFR HDR Plasmid (h2) - sc-417022-HDR-2 from Santa Cruz Biotechnology

Prices $385.00
Sizes 20 µg
Species Reactivities Human

DHFR CRISPR/Cas9 KO Plasmid (h2) - sc-417022-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $385.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human DHFR (NM_000791.3) - SHH277613 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DHFR(NM_000791.3) - SHH003539 from Creative biogene

Category siRNA
Species Reactivities Human

Human DHFR siRNA - orb261695 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DHFR shRNA Plasmid (Human) - CHH1193 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DHFR miRNA 3'UTR clone - MiUTR1H-02806 from Creative biogene

Species Reactivities Human
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