POLD1

Gene Symbol POLD1
Entrez Gene 5424
Alt Symbol CDC2, CRCS10, MDPL, POLD
Species Human
Gene Type protein-coding
Description polymerase (DNA directed), delta 1, catalytic subunit
Other Description CDC2 homolog|DNA polymerase delta catalytic subunit|DNA polymerase subunit delta p125|polymerase (DNA directed), delta 1, catalytic subunit 125kDa
Swissprots Q96H98 P28340 Q8NER3
Accessions AAM76971 EAW71856 EAW71857 P28340 AA236879 AB209560 BAD92797 BC008800 AAH08800 BM193218 CD101690 DQ234348 ABB29977 DQ895953 ABM86879 EU176381 ABW03832 M80397 AAA58439 M81735 AAA35768 XM_005259008 XP_005259065 XM_011527038 XP_011525340 XM_011527039 XP_011525341 XR_935835 NM_001256849 NP_001243778 NM_001308632 NP_001295561 NM_002691 NP_002682 NR_046402
Function Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
Subcellular Location Nucleus.
Tissue Specificity Expressed across a panel of tissues, with high levels of expression in heart and lung. {ECO:0000269|PubMed:23770608}.
Top Pathways HTLV-I infection, Nucleotide excision repair, Base excision repair, Homologous recombination, Mismatch repair

DNA pol δ cat (A-9) - sc-17776 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Cat
Clonality Monoclonal
DNA pol δ cat (A-9): sc-17776. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing nuclear staining of follicle, non-follicle and epithelial cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

DNA pol δ cat (C-2) - sc-17777 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Cat
Clonality Monoclonal
DNA pol δcat (C-2): sc-17777. Western blot analysis of DNA pol δ cat expression in HeLa (A), NIH/3T3 (B) and KNRK (C) whole cell lysates.

DNA pol δ cat (C-20) - sc-8797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Cat
Clonality Polyclonal
DNA pol δ cat (C-20): sc-8797. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

DNA pol δ cat (E-3) - sc-55499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Cat
Clonality Monoclonal
DNA pol δ cat (E-3): sc-55499. Western blot analysis of DNA pol δ cat expression in HeLa whole cell lysate.

DNA pol δ cat (5G1) - sc-53856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Cat
Clonality Monoclonal
DNA pol δ cat (5G1): sc-53856. Western blot analysis of DNA pol δ cat expression in HL-60 whole cell lysate.

DNA pol δ cat (H-300) - sc-10784 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Cat
Clonality Polyclonal
DNA pol δ cat (H-300): sc-10784. Immunoperoxidase staining of methanol-fixed Jurkat cells showing nuclear staining.

DNA pol δ cat (N-19) - sc-8796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Cat
Clonality Polyclonal
DNA pol δ cat (N-19): sc-8796. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

DNA pol δ cat (22) - sc-135884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Cat
Clonality Monoclonal
DNA pol δ cat (22): sc-135884. Western blot analysis of DNA pol δ cat expression in Jurkat whole cell lysate.

Anti-DNA Polymerase delta, catalytic subunit antibody - ab196561 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DNA Polymerase delta, catalytic subunit antibody (ab196561) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : SW480 cell extractLane 3 : Mouse spleen cell extract

Anti-DNA Polymerase delta, catalytic subunit antibody - ab168827 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DNA Polymerase delta, catalytic subunit antibody (ab168827) at 0.1 µg/mlLane 1 : HeLa whole cell lysateLane 2 : 293T whole cell lysateLane 3 : Jurkat whole cell lysateLane 4 : TCMK-1 whole cell lysateLane 5 : NIH3T3 whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-DNA Polymerase delta, catalytic subunit antibody - ab92704 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DNA Polymerase delta, catalytic subunit antibody (ab92704) at 1/500 dilutionLane 1 : K562 cells (without peptide)Lane 2 : K562 cells (with peptide)Lysates/proteins at 30 µg per lane.

Anti-DNA Polymerase delta, catalytic subunit antibody [2761C6a] - ab54282 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2761C6a
Staining of recombinant immunising protein using anti-DNA Polymerase delta, catalytic subunit [2761C6a] (ab54282).

Anti-DNA Polymerase delta, catalytic subunit antibody [607] - ab10362 from Abcam

Prices $392.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 607

Anti-DNA Polymerase delta, catalytic subunit antibody [EPR15118] - ab186407 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15118
All lanes : Anti-DNA Polymerase delta, catalytic subunit antibody [EPR15118] (ab186407) at 1/10000 dilutionLane 1 : MOLT4 cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLane 4 : K562 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat anti-rabbit IgG, (H+L), peroxidase conjugate at 1/1000 dilution

Anti-POLD1 Antibody (aa1-140) - LS-C19967 from LifeSpan Bioscience

Prices $295.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-POLD1 Antibody (aa1-140, clone 6196) - LS-C20113 from LifeSpan Bioscience

Prices $335.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 6196

Anti-POLD1 Antibody - LS-C75013 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-POLD1 Antibody (aa1051-1100) - LS-C119908 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from K562 cells, using POLD1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-POLD1 Antibody (clone 2761C6a) - LS-C184547 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2761C6a
Western blot of immunized recombinant protein using POLD1 antibody.

Anti-POLD1 Antibody (clone 5G1) - LS-C179689 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 5G1

Anti-POLD1 Antibody (Asp1091) - LS-C177825 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of DNA pol cat antibody in extracts from K562 cells.

Anti-POLD1 Antibody (aa50-100) - LS-C290650 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse PolD1 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-PolD1 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-POLD1 Antibody (aa930-980) - LS-C290652 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse PolD1 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-PolD1 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-POLD1 Antibody (aa850-900) - LS-C290651 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse PolD1 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-PolD1 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-POLD1 Antibody (aa710-739) - LS-C163837 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of POLD1 Antibody in Jurkat cell line lysates (35 ug/lane). POLD1 (arrow) was detected using the purified antibody.
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