| Gene Symbol | POLD1 |
|---|---|
| Entrez Gene | 5424 |
| Alt Symbol | CDC2, CRCS10, MDPL, POLD |
| Species | Human |
| Gene Type | protein-coding |
| Description | polymerase (DNA directed), delta 1, catalytic subunit |
| Other Description | CDC2 homolog|DNA polymerase delta catalytic subunit|DNA polymerase subunit delta p125|polymerase (DNA directed), delta 1, catalytic subunit 125kDa |
| Swissprots | Q96H98 P28340 Q8NER3 |
| Accessions | AAM76971 EAW71856 EAW71857 P28340 AA236879 AB209560 BAD92797 BC008800 AAH08800 BM193218 CD101690 DQ234348 ABB29977 DQ895953 ABM86879 EU176381 ABW03832 M80397 AAA58439 M81735 AAA35768 XM_005259008 XP_005259065 XM_011527038 XP_011525340 XM_011527039 XP_011525341 XR_935835 NM_001256849 NP_001243778 NM_001308632 NP_001295561 NM_002691 NP_002682 NR_046402 |
| Function | Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Expressed across a panel of tissues, with high levels of expression in heart and lung. {ECO:0000269|PubMed:23770608}. |
| Top Pathways | HTLV-I infection, Nucleotide excision repair, Base excision repair, Homologous recombination, Mismatch repair |