| Gene Symbol |
Izumo1
|
| Entrez Gene |
73456
|
| Alt Symbol |
1700058F15Rik, Izumo
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
izumo sperm-egg fusion 1
|
| Other Description |
OBF|izumo sperm-egg fusion protein 1|oocyte binding/fusion factor|sperm-specific protein Izumo
|
| Swissprots |
Q9D9J7
|
| Accessions |
EDL22878 Q9D9J7 AB195681 BAD91011 AK006830 BAB24761 BC139270 BC152920 AAI52921 XM_006541222 XP_006541285 NM_001018013 NP_001018013
|
| Function |
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. {ECO:0000269|PubMed:15759005, ECO:0000269|PubMed:24739963}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction. {ECO:0000269|PubMed:15759005, ECO:0000269|PubMed:19658160}.
|