Gene Symbol | Izumo1 |
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Entrez Gene | 73456 |
Alt Symbol | 1700058F15Rik, Izumo |
Species | Mouse |
Gene Type | protein-coding |
Description | izumo sperm-egg fusion 1 |
Other Description | OBF|izumo sperm-egg fusion protein 1|oocyte binding/fusion factor|sperm-specific protein Izumo |
Swissprots | Q9D9J7 |
Accessions | EDL22878 Q9D9J7 AB195681 BAD91011 AK006830 BAB24761 BC139270 BC152920 AAI52921 XM_006541222 XP_006541285 NM_001018013 NP_001018013 |
Function | Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. {ECO:0000269|PubMed:15759005, ECO:0000269|PubMed:24739963}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction. {ECO:0000269|PubMed:15759005, ECO:0000269|PubMed:19658160}. |
IZUMO1 CRISPR/Cas9 KO Plasmid (m) - sc-428574 from Santa Cruz Biotechnology
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IZUMO1 HDR Plasmid (m) - sc-428574-HDR from Santa Cruz Biotechnology
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IZUMO1 Double Nickase Plasmid (m) - sc-428574-NIC from Santa Cruz Biotechnology
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IZUMO1 Double Nickase Plasmid (m2) - sc-428574-NIC-2 from Santa Cruz Biotechnology
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IZUMO1 CRISPR Activation Plasmid (m) - sc-428574-ACT from Santa Cruz Biotechnology
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IZUMO1 CRISPR Activation Plasmid (m2) - sc-428574-ACT-2 from Santa Cruz Biotechnology
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IZUMO1 Lentiviral Activation Particles (m) - sc-428574-LAC from Santa Cruz Biotechnology
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IZUMO1 Lentiviral Activation Particles (m2) - sc-428574-LAC-2 from Santa Cruz Biotechnology
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IZUMO1 siRNA (m) - sc-75352 from Santa Cruz Biotechnology
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IZUMO1 shRNA Plasmid (m) - sc-75352-SH from Santa Cruz Biotechnology
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IZUMO1 shRNA (m) Lentiviral Particles - sc-75352-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU202631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN34040 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34040 from Sigma-Aldrich
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IZUMO1 siRNA (Mouse) - CRM8998 from Cohesion Biosciences
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IZUMO1, siRNA - MBS8211899 from MyBioSource
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shRNA set against Mouse IZUMO1 (NM_001018013.1) - SHH321839 from Creative biogene
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shRNA set against Mouse Izumo1(NM_001018013.1) - SHL185364 from Creative biogene
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IZUMO1 shRNA Plasmid (Mouse) - CHM8998 from Cohesion Biosciences
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IZUMO1 miRNA 3'UTR clone - MiUTR1M-06176 from Creative biogene
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