| Gene Symbol | Izumo1 |
|---|---|
| Entrez Gene | 73456 |
| Alt Symbol | 1700058F15Rik, Izumo |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | izumo sperm-egg fusion 1 |
| Other Description | OBF|izumo sperm-egg fusion protein 1|oocyte binding/fusion factor|sperm-specific protein Izumo |
| Swissprots | Q9D9J7 |
| Accessions | EDL22878 Q9D9J7 AB195681 BAD91011 AK006830 BAB24761 BC139270 BC152920 AAI52921 XM_006541222 XP_006541285 NM_001018013 NP_001018013 |
| Function | Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. {ECO:0000269|PubMed:15759005, ECO:0000269|PubMed:24739963}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction. {ECO:0000269|PubMed:15759005, ECO:0000269|PubMed:19658160}. |
Izumo sperm-egg fusion protein 1, Izumo1, Mouse, ELISA Kit - E1556m from ARP American Research Products
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izumo sperm-egg fusion 1, ELISA Kit - MBS9316627 from MyBioSource
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Mouse Izumo1 ELISA Kit - E057628 from Biobool
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IZUMO1 ELISA Kit (Mouse) (OKEH05414) - OKEH05414 from Aviva Systems Biology
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Izumo sperm-egg fusion protein 1, ELISA Kit - MBS2887209 from MyBioSource
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