Podxl

Gene Symbol Podxl
Entrez Gene 192181
Alt Symbol PC, PCLP-1, podocalyxin
Species Rat
Gene Type protein-coding
Description podocalyxin-like
Other Description podocalyxin|podocalyxin-like protein 1
Swissprots Q9WTQ2 Q6IRK7 Q9R068
Accessions EDM15282 Q9WTQ2 AB020726 BAA78375 AF109393 AAF14238 BC070886 AAH70886 FQ224973 XM_008762758 XP_008760980 NM_138848 NP_620203
Function Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:10982412}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:11457882}. Cell projection, microvillus {ECO:0000269|PubMed:11457882}. Membrane raft {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans- Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial
Tissue Specificity Glomerular epithelium cell (podocyte) (at protein level). {ECO:0000269|PubMed:11457882}.

Podocalyxin / PODXL antibody - PAB8511 from Acris Antibodies

Prices $760.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extract from rat liver ( lane 1 ) , rat kidney ( lane 2 ) and rat heart ( lane3 ) , using Podxl polyclonal antibody ( Cat # PAB8511 ) .

Anti-PODXL polyclonal antibody - DPAB-DC816 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-Podocalyxin-like protein 1 Antibody - ABD27 from EMD Millipore

Prices $319.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Monoclonal Antibody to Protein C (PROC) - MAA734Ra21 from Cloud-clone

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Protein C (PROC) - PAA734Ra01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Monoclonal Antibody to Podocalyxin (PCX) - MAA768Ra21 from Cloud-clone

Host Mouse
Clonality Monoclonal

Polyclonal Antibody to Podocalyxin (PCX) - PAA768Ra01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

anti-Gp200 antibody [PN-15] - ARG62617 from Arigo Biolaboratories

anti-PODXL antibody - ARG64235 from Arigo Biolaboratories

ARG64235 anti-PODXL antibody WB image Western Blot: Human Kisney lysate (35 µg protein in RIPA buffer) stained with ARG64235 anti-PODXL antibody at 1 µg/ml dilution.

Podocalyxin Antibody - abx130321 from Abbexa

Host Rabbit
Clonality Polyclonal

Podocalyxin, Polyclonal Antibody - MBS2027925 from MyBioSource

Prices $160.00, $310.00, $480.00
Sizes 20 µg, 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX) Polyclonal Antibody - CAU27199 from Biomatik

Prices $109.00, $254.00, $363.00, $580.00
Sizes 10 μg, 50 μg, 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal

Podocalyxin, Polyclonal Antibody - MBS7602830 from MyBioSource

Prices $320.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047089 from MyBioSource

Prices $815.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047090 from MyBioSource

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047091 from MyBioSource

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047092 from MyBioSource

Prices $555.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047093 from MyBioSource

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047094 from MyBioSource

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047095 from MyBioSource

Prices $835.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047096 from MyBioSource

Prices $350.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047097 from MyBioSource

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047098 from MyBioSource

Prices $565.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047099 from MyBioSource

Prices $350.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Podocalyxin (PCX), Polyclonal Antibody - MBS2047100 from MyBioSource

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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