Podxl

Gene Symbol	Podxl
Entrez Gene	192181
Alt Symbol	PC, PCLP-1, podocalyxin
Species	Rat
Gene Type	protein-coding
Description	podocalyxin-like
Other Description	podocalyxin|podocalyxin-like protein 1
Swissprots	Q9WTQ2 Q6IRK7 Q9R068
Accessions	EDM15282 Q9WTQ2 AB020726 BAA78375 AF109393 AAF14238 BC070886 AAH70886 FQ224973 XM_008762758 XP_008760980 NM_138848 NP_620203
Function	Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:10982412}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:11457882}. Cell projection, microvillus {ECO:0000269|PubMed:11457882}. Membrane raft {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans- Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial
Tissue Specificity	Glomerular epithelium cell (podocyte) (at protein level). {ECO:0000269|PubMed:11457882}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Podocalyxin, PCX, Rat, ELISA Kit - CSB-E13946r from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Podocalyxin, Podxl, Rat, ELISA Kit - E0768r from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Podocalyxin, Rat, ELISA Kit - E02P0069 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/ml

Rat PC/CPG ELISA Kit - RP0626 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Rat PC ELISA Kit - RP0624 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Rat PC ELISA Kit - RP0055 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Rat PC(Pyruvate Carboxylase) ELISA Kit - E-EL-R2513 from Elabscience Category ELISA Kit Sensitivity 0.47 ng/mL Range 0.78—50 ng/mL

PC, ELISA Kit - MBS2516178 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.469ng/mL Range 0.781-50ng/mL

Rat Podocalyxin,PCX ELISA Kit - CSB-E13946r from Cusabio Category ELISA Kit Sensitivity 0.39 ng/ml Range 1.56 ng/ml-100 ng/ml

Rat Protein Carbonyl ELISA - E02P0048 from BlueGene Biotech Category ELISA Kit

ELISA Kit for Protein C (PROC) - SEA734Ra from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.58ng/mL. Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

ELISA Kit for Podocalyxin (PCX) - SEA768Ra from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.59ng/mL. Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

Rat Podocalyxin (PCX) ELISA Kit - EKU06722 from Biomatik Category ELISA Kit Prices $718.00, $3,196.00, $5,817.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.59 ng/mL Range 1.56-100 ng/mL

Rat PROC(Protein C) ELISA Kit - E-EL-R0800 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.94 ng/mL Range 1.56~100 ng/mL

Rat Podocalyxin ELISA Kit - abx155991 from Abbexa Category ELISA Kit Range 1.56 ng/ml - 100 ng/ml

Rat Podocalyxin ELISA Kit - abx255901 from Abbexa Category ELISA Kit Sensitivity 0.938 ng/ml Range 1.563 ng/ml - 100 ng/ml

PCX (Podocalyxin), CLIA Kit - MBS2532132 from MyBioSource Category CLIA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

PCX (Podocalyxin), CLIA Kit - MBS2531142 from MyBioSource Category CLIA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

PCX (Podocalyxin), CLIA Kit - MBS2532473 from MyBioSource Category CLIA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

Pc - EKR1114 from Nordic BioSite Sensitivity 0.469ng/ml Range 0.781-50ng/ml

Rat Podxl ELISA Kit - E094033 from Biobool Category ELISA Kit

Rat PC ELISA Kit - ERP0055 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Rat PC ELISA Kit - ERP0624 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Rat PC/CPG ELISA Kit - ERP0626 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

PODXL ELISA Kit (Rat) (OKCD02761) - OKCD02761 from Aviva Systems Biology Category ELISA Kit Prices $535.00 Sizes 100 ng Sensitivity 0.59 ng/mL Range 1.56-100 ng/mL

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