Podxl

Gene Symbol	Podxl
Entrez Gene	192181
Alt Symbol	PC, PCLP-1, podocalyxin
Species	Rat
Gene Type	protein-coding
Description	podocalyxin-like
Other Description	podocalyxin|podocalyxin-like protein 1
Swissprots	Q9WTQ2 Q6IRK7 Q9R068
Accessions	EDM15282 Q9WTQ2 AB020726 BAA78375 AF109393 AAF14238 BC070886 AAH70886 FQ224973 XM_008762758 XP_008760980 NM_138848 NP_620203
Function	Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:10982412}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:11457882}. Cell projection, microvillus {ECO:0000269|PubMed:11457882}. Membrane raft {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans- Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial
Tissue Specificity	Glomerular epithelium cell (podocyte) (at protein level). {ECO:0000269|PubMed:11457882}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Recombinant Protein C (PROC) - RPA734Ra01 from Cloud-clone Category Protein Source E.coli Species Rat

Recombinant Podocalyxin (PCX) - RPA768Ra01 from Cloud-clone Category Protein Source E.coli Species Rat

Recombinant Rat Podocalyxin(Podxl) - CSB-YP893876RA CSB-EP893876RA CSB-BP893876RA CSB-MP893876RA from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Rat

Podocalyxin Protein (Recombinant) - abx167620 from Abbexa Category Protein Source Rat Species Rat

Podocalyxin, Recombinant Protein - MBS2030696 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Podocalyxin, Recombinant Protein - MBS2029269 from MyBioSource Category Protein Prices $190.00, $400.00, $620.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Rat

Podocalyxin, Recombinant Protein - MBS1349313 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,130.00, $1,180.00, $1,360.00, $1,360.00, $1,795.00, $2,255.00, $2,255.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 1 mg (E-Coli), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Rat PODXL Protein - PODXL-4557R from Creative Biomart Category Protein Source Mammalian Cells Species Rat

Podxl Recombinant Protein (OPCA03089) - OPCA03089 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Rat

Rat Podxl protein - orb358312 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Rat

Recombinant Podocalyxin (PCX) - RPU53341 from Biomatik Category Protein Prices $196.00, $401.00, $614.00, $731.44 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Rat

PODXL Recombinant Protein (OPCD06034) - OPCD06034 from Aviva Systems Biology Category Protein Source E.coli Species Rat

Recombinant Rattus norvegicus Podocalyxin - AP73150 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast

Podocalyxin, Recombinant Protein - MBS9422846 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Rat

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