| Gene Symbol |
Podxl
|
| Entrez Gene |
192181
|
| Alt Symbol |
PC, PCLP-1, podocalyxin
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
podocalyxin-like
|
| Other Description |
podocalyxin|podocalyxin-like protein 1
|
| Swissprots |
Q9WTQ2 Q6IRK7 Q9R068
|
| Accessions |
EDM15282 Q9WTQ2 AB020726 BAA78375 AF109393 AAF14238 BC070886 AAH70886 FQ224973 XM_008762758 XP_008760980 NM_138848 NP_620203
|
| Function |
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. {ECO:0000269|PubMed:10982412}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000269|PubMed:11457882}. Cell projection, microvillus {ECO:0000269|PubMed:11457882}. Membrane raft {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans- Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Forms granular, punctuated pattern, forming patches, preferentially adopting a polar distribution, located on the migrating poles of the cell or forming clusters along the terminal ends of filipodia establishing contact with the endothelial
|
| Tissue Specificity |
Glomerular epithelium cell (podocyte) (at protein level). {ECO:0000269|PubMed:11457882}.
|