ANGPT1

Gene Symbol	ANGPT1
Entrez Gene	284
Alt Symbol	AGP1, AGPT, ANG1
Species	Human
Gene Type	protein-coding
Description	angiopoietin 1
Other Description	ANG-1|angiopoietin-1
Swissprots	Q15389 Q5HYA0
Accessions	EAW91909 EAW91910 EAW91911 EAW91912 Q15389 AB084454 BAB91325 AK300319 BAG62071 AK304717 BAG65481 AL700429 AW069541 AY055342 AAL59669 AY121504 AAM81745 AY124380 AAM92271 BC029406 AAH29406 BC152411 AAI52412 BC152419 AAI52420 BC166662 AAI66662 BX648814 CAI45984 CX867178 D13628 BAA02793 EU831933 ACE87374 EU832028 ACE86690 U83508 AAB50557 XR_928319 NM_001146 NP_001137 NM_001199859 NP_001186788 NM_139290
Function	Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adh
Subcellular Location	Secreted.
Top Pathways	Rheumatoid arthritis, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Angiopoietin 1 (ANG1) Human ELISA Kit - ab99972 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 30 pg/ml Range 74 pg/ml - 18000 pg/ml

Human ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F3958 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 0.11 ng/ml Range 156-10000 pg/ml

Human ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F2576 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 156-10000 pg/ml

Rat ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F2955 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 156-10000 pg/ml

Mouse ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F2956 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 156 pg/ml Range 156-10000 pg/ml

Rat ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F5442 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 12.8 pg/ml Range 156-10000 pg/ml

Mouse ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F5441 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 156-10000 pg/ml

Bovine ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F6220 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.625 ng/ml Range 156-10000 pg/ml

Human ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F423 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 24.69 pg/ml Range 156-10000 pg/ml

Human ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F675 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 156-10000 pg/ml

Dog ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F7771 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.93 ng/ml Range 156-10000 pg/ml

Bovine ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F10329 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 1.384 ng/ml Range 156-10000 pg/ml

Human ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F10188 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 156-10000 pg/ml

Rat ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F10827 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 6.25 Range 156-10000 pg/ml

Human ANGPT1 / Angiopoietin-1 ELISA Kit (Sandwich ELISA) - LS-F10826 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 46.88 Range 156-10000 pg/ml

Human Angiopoietin-1 ELISA Kit - RAB0015 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human Angiopoietin-1 Biotin Fluorokine Flow Cytometry Kit - NFANG1 from R&D Systems Prices $405.00 Sizes 1 kit

Human Angiopoietin-1 Luminex Performance Assay - LAN923 from R&D Systems

Human Angiopoietin-1 Magnetic Luminex Performance Assay - LANM923 from R&D Systems

Human Angiopoietin-1 Quantikine ELISA Kit - DANG10 from R&D Systems Category ELISA Kit Prices $519.00, $2,491.00, $16,868.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 10.3 pg/mL Range 62.5 - 4,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Platelet-poor Citrate Plasma, Saliva, Human Milk)

Human Angiopoietin-1 Quantikine PharmPak (50 Plates) - PDANG10 from R&D Systems Category ELISA Kit Sensitivity 10.3 pg/mL Range 62.5 - 4,000 pg/mL (Serum, Heparin Plasma, Saliva, Cell Culture Supernates, Human Milk, EDTA Plasma, Platelet-poor Citrate Plasma)

Human Angiopoietin-1 Quantikine SixPak (6 Plates) - SANG10 from R&D Systems Category ELISA Kit Sensitivity 10.3 pg/mL Range 62.5 - 4,000 pg/mL (Serum, Heparin Plasma, Saliva, Cell Culture Supernates, Human Milk, EDTA Plasma, Platelet-poor Citrate Plasma)

Human Angiopoietin-1 DuoSet ELISA - DY923 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 156.00 - 10,000 pg/mL

Quantikine Immunoassay Control Set 841 Human Angiopoietin-1 - QC42 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human Angiopoietin 1 ELISA kit - 55R-2191 from Fitzgerald Category ELISA Kit Prices $495.00 Sizes 96 tests

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