ANGPT1

Gene Symbol	ANGPT1
Entrez Gene	284
Alt Symbol	AGP1, AGPT, ANG1
Species	Human
Gene Type	protein-coding
Description	angiopoietin 1
Other Description	ANG-1|angiopoietin-1
Swissprots	Q15389 Q5HYA0
Accessions	EAW91909 EAW91910 EAW91911 EAW91912 Q15389 AB084454 BAB91325 AK300319 BAG62071 AK304717 BAG65481 AL700429 AW069541 AY055342 AAL59669 AY121504 AAM81745 AY124380 AAM92271 BC029406 AAH29406 BC152411 AAI52412 BC152419 AAI52420 BC166662 AAI66662 BX648814 CAI45984 CX867178 D13628 BAA02793 EU831933 ACE87374 EU832028 ACE86690 U83508 AAB50557 XR_928319 NM_001146 NP_001137 NM_001199859 NP_001186788 NM_139290
Function	Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adh
Subcellular Location	Secreted.
Top Pathways	Rheumatoid arthritis, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Angiopoietin 1 full length protein - ab69492 from Abcam Category Protein Prices $315.00 Sizes 20 µg Source HeLa cells Species Human

Angiopoietin 1 peptide - ab109637 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Angiopoietin 1 protein fragment - ab113163 from Abcam Category Protein Prices $309.00 Sizes 100 µg Source E. coli Species Human

Human Angiopoietin 1 protein fragment - ab109138 from Abcam Category Protein Prices $309.00 Sizes 10 µg Source E. coli Species Human

ANGPT1 / Angiopoietin-1 Antibody Blocking Peptide - LS-E220 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ANGPT1 / Angiopoietin-1 Antibody Blocking Peptide - LS-E27451 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ANGPT1 / Angiopoietin-1 Antibody Blocking Peptide - LS-E23025 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ANGPT1 / Angiopoietin-1 Antibody Blocking Peptide - LS-E23026 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Human Angiopoietin-1 Biologically Active Protein - NBP2-35345 from Novus Biologicals Category Protein Prices $69.00, $169.00 Sizes 5 µg, 20 µg Source E. coli Species Human

Angiopoietin-1 Partial Recombinant Protein - H00000284-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Angiopoietin-1 Recombinant Protein - H00000284-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Angiopoietin-1 Peptide - NBP1-96997 from Novus Biologicals Category Peptide Prices $199.00 Sizes 50 µg

Recombinant Human Angiopoietin-1 Protein - NBP1-72477 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

ANGPT1-Antibody-C-term-Blocking-Peptide - BP10451b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Angiopoietin 1 Recombinant Protein (Active) - GTX48475-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source Human Species Human

Recombinant Human Angiopoietin-1 - 923-AN-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser20-Phe498, with a C-terminal 6-His tag

Recombinant Human Angiopoietin-1, CF - 923-AN-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser20-Phe498, with a C-terminal 6-His tag

Recombinant rat Angiopoietin-1 (OPCA01199) - OPCA01199 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Rat

Human ANGPT1 protein - orb167888 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human ANGPT1 protein - orb244823 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Angiopoietin 1 Blocking Peptide (Mouse) - 30R-AA012 from Fitzgerald Category Peptide Prices $209.00 Sizes 100 µg Source COS cells Species Mouse

Angiopoietin 1 protein - 30R-AA041 from Fitzgerald Category Protein Prices $225.00 Sizes 20 µg Source HeLa cells

Angiopoietin 1 protein - 30R-AA011 from Fitzgerald Category Protein Prices $175.00, $375.00 Sizes 5 µg, 20 µg

ANGPT1 protein - 30R-2085 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human Angiopoietin 1 Protein - abx065317 from Abbexa Category Protein Source E.coli Species Human

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