ANGPT1

Gene Symbol ANGPT1
Entrez Gene 284
Alt Symbol AGP1, AGPT, ANG1
Species Human
Gene Type protein-coding
Description angiopoietin 1
Other Description ANG-1|angiopoietin-1
Swissprots Q15389 Q5HYA0
Accessions EAW91909 EAW91910 EAW91911 EAW91912 Q15389 AB084454 BAB91325 AK300319 BAG62071 AK304717 BAG65481 AL700429 AW069541 AY055342 AAL59669 AY121504 AAM81745 AY124380 AAM92271 BC029406 AAH29406 BC152411 AAI52412 BC152419 AAI52420 BC166662 AAI66662 BX648814 CAI45984 CX867178 D13628 BAA02793 EU831933 ACE87374 EU832028 ACE86690 U83508 AAB50557 XR_928319 NM_001146 NP_001137 NM_001199859 NP_001186788 NM_139290
Function Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adh
Subcellular Location Secreted.
Top Pathways Rheumatoid arthritis, PI3K-Akt signaling pathway, Rap1 signaling pathway

Human ANGPT1 Gene cDNA Clone - orb141801 from Biorbyt

Prices $255.00
Sizes 10 μg
Species Human

Human-ANGPT1-cDNA-Clone - DC05932 from Abgent, a WuXi AppTec company

Prices $198.45
Sizes 10 µg
Species Human
Accession BC029406

ANGPT1 - MBS1265664 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC029406

Human ANGPT1 cDNA clone(NM_001146.3) - CDFH000777 from Creative Biomart

Species Human
Accession NM_001146.3

Human ANGPT1 ORF clone(NM_001146.3) - CDCL182686 from Creative Biomart

Species Human
Accession NM_001146.3

Human ANGPT1 ORF Clone(NM_001146.3) - CDCR353178 from Creative Biomart

Species Human
Accession NM_001146.3

Human ANGPT1 ORF Clone(NM_001146.3) - CDCR353179 from Creative Biomart

Species Human
Accession NM_001146.3

Human ANGPT1 ORF Clone(NM_001146.3) - CDCR353181 from Creative Biomart

Species Human
Accession NM_001146.3

Human ANGPT1 ORF Clone(NM_001146.3) - CDCL153795 from Creative Biomart

Species Human
Accession NM_001146.3

Human ANGPT1 ORF clone(NM_001146.3) - CDCL182686 from Creative biogene

Species Human

Human ANGPT1 ORF Clone (BC029406) - CDCS408575 from Creative biogene

Species Human
Accession Q15389

Human ANGPT1 cDNA Clone(NM_001146.3) - CDFH000777 from Creative biogene

Species Human
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