ANGPT1

Gene Symbol	ANGPT1
Entrez Gene	284
Alt Symbol	AGP1, AGPT, ANG1
Species	Human
Gene Type	protein-coding
Description	angiopoietin 1
Other Description	ANG-1|angiopoietin-1
Swissprots	Q15389 Q5HYA0
Accessions	EAW91909 EAW91910 EAW91911 EAW91912 Q15389 AB084454 BAB91325 AK300319 BAG62071 AK304717 BAG65481 AL700429 AW069541 AY055342 AAL59669 AY121504 AAM81745 AY124380 AAM92271 BC029406 AAH29406 BC152411 AAI52412 BC152419 AAI52420 BC166662 AAI66662 BX648814 CAI45984 CX867178 D13628 BAA02793 EU831933 ACE87374 EU832028 ACE86690 U83508 AAB50557 XR_928319 NM_001146 NP_001137 NM_001199859 NP_001186788 NM_139290
Function	Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adh
Subcellular Location	Secreted.
Top Pathways	Rheumatoid arthritis, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ANGPT1 overexpression lysate - LY400458 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

ANGPT1 293 Cell Lysate - 400468 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Angiopoietin-1 Overexpression Lysate (Native) - NBL1-07521 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

ANGPT1 Over-expression Lysate Product - GWB-CEC5C7 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Cynomolgus Angiopoietin 1 / ANG1 / ANGPT1 HEK293 Cell Lysate (WB positive control) - 90025-C07HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Panoply™ Human ANGPT1 Knockdown Stable Cell Line - CSC-DC000591 from Creative biogene Category Cell Line Species Human

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