| Gene Symbol | DYNC1I1 |
|---|---|
| Entrez Gene | 1780 |
| Alt Symbol | DNCI1, DNCIC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynein, cytoplasmic 1, intermediate chain 1 |
| Other Description | DH IC-1|cytoplasmic dynein 1 intermediate chain 1|cytoplasmic dynein intermediate chain 1|dynein intermediate chain 1, cytosolic|dynein, cytoplasmic, intermediate polypeptide 1 |
| Swissprots | G5E9K1 Q8TBF7 F5H050 O14576 B4DME3 Q9Y2X1 |
| Accessions | AAB67047 AAB70113 AAS01994 AAS07455 EAL24126 EAW76751 EAW76752 EAW76753 EAW76754 EAW76755 O14576 AF063228 AAC33443 AF123074 AAD26852 AK091339 BAC03639 AK297427 BAG59855 AK309419 AK313148 BAG35966 BC012504 BC022540 AAH22540 BC032945 AAH32945 BC037854 AAH37854 BC053542 AAH53542 BP307571 DA491512 DB343806 XM_011515861 XP_011514163 XM_011515862 XP_011514164 XM_011515863 XP_011514165 XM_011515864 XP_011514166 NM_001135556 NP_001129028 NM_001135557 NP_001129029 NM_001278421 NP_001265350 NM_001278422 NP_001265351 NM_004411 NP_004402 |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19229290}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19229290}. |
| Top Pathways | Vasopressin-regulated water reabsorption, Phagosome, Salmonella infection |
Dynein IC1, cytosolic CRISPR/Cas9 KO Plasmid (h) - sc-405213 from Santa Cruz Biotechnology
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Dynein IC1, cytosolic HDR Plasmid (h) - sc-405213-HDR from Santa Cruz Biotechnology
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Dynein IC1, cytosolic Double Nickase Plasmid (h) - sc-405213-NIC from Santa Cruz Biotechnology
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Dynein IC1, cytosolic Double Nickase Plasmid (h2) - sc-405213-NIC-2 from Santa Cruz Biotechnology
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Dynein IC1, cytosolic CRISPR Activation Plasmid (h) - sc-405213-ACT from Santa Cruz Biotechnology
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Dynein IC1, cytosolic CRISPR Activation Plasmid (h2) - sc-405213-ACT-2 from Santa Cruz Biotechnology
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Dynein IC1, cytosolic Lentiviral Activation Particles (h) - sc-405213-LAC from Santa Cruz Biotechnology
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Dynein IC1, cytosolic Lentiviral Activation Particles (h2) - sc-405213-LAC-2 from Santa Cruz Biotechnology
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Dynein IC1, cytosolic siRNA (h) - sc-44673 from Santa Cruz Biotechnology
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Dynein IC1, cytosolic shRNA Plasmid (h) - sc-44673-SH from Santa Cruz Biotechnology
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Dynein IC1, cytosolic shRNA (h) Lentiviral Particles - sc-44673-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU076551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7582 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7582 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06474 from Sigma-Aldrich
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DYNC1I1 siRNA (Human) - CRH1237 from Cohesion Biosciences
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DYNC1I1 - MBS8218762 from MyBioSource
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shRNA set against Human DYNC1I1 (NM_004411.4) - SHH282109 from Creative biogene
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Human DYNC1I1 siRNA - orb261739 from Biorbyt
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DYNC1I1 shRNA Plasmid (Human) - CHH1237 from Cohesion Biosciences
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DYNC1I1 miRNA 3'UTR clone - MiUTR3H-06258 from Creative biogene
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DYNC1I1 miRNA 3'UTR clone - MiUTR3H-06259 from Creative biogene
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DYNC1I1 miRNA 3'UTR clone - MiUTR3H-06260 from Creative biogene
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