GAPDH

Gene Symbol	GAPDH
Entrez Gene	2597
Alt Symbol	G3PD, GAPD, HEL-S-162eP
Species	Human
Gene Type	protein-coding
Description	glyceraldehyde-3-phosphate dehydrogenase
Other Description	aging-associated gene 9 protein|epididymis secretory sperm binding protein Li 162eP|peptidyl-cysteine S-nitrosylase GAPDH
Swissprots	E7EUT4 Q53X65 P00354 P04406
Accessions	AAA53191 AAP88932 AEQ28035 AEQ28036 AEQ28037 EAW88786 EAW88787 P04406 AB062273 BAB93466 AF261085 AAF99678 AJ844644 CAH59755 AJ844645 CAH59756 AK026525 AK299448 BAG61421 AK308198 AY007133 AAG01996 AY633612 AAV33305 BC001601 AAH01601 BC004109 AAH04109 BC009081 AAH09081 BC013310 AAH13310 BC020308 BC023632 AAH23632 BC025925 AAH25925 BC026907 AAH26907 BC029340 BC029618 AAH29618 BC083511 AAH83511 BE893087 BG724119 BI463134 BM763361 BT006893 AAP35539 BU155402 CR407671 CAG28599 DQ403057 ABD77190 DQ891557 ABM82483 DQ894744 ABM85670 EF036498 ABO65084 EU668321 ACF94474 HQ727992 AET97565 HY000136 HY004110 HY022295 HY046784 J02642 AAA52496 M17851 AAA86283 M28283 AAA52519 M33197 AAA52518 M36164 X01677 CAA25833 X53778 CAA37794 NM_001256799 NP_001243728 NM_001289745 NP_001276674 NM_001289746 NP_001276675 NM_002046 NP_002037
Function	Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D- glyceroyl phosphate. Component of the GAIT (gamma interferon- activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibit
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:12829261}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12829261}. Membrane {ECO:0000269|PubMed:12829261}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Translocates to the nucleus following S- nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions. {ECO:0000250}.
Top Pathways	Glycolysis / Gluconeogenesis, Alzheimer's disease, Biosynthesis of amino acids, Carbon metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GAPDH gene - orb90707 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human G3PD Gene - orb143435 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-GAPDH-cDNA-Clone - DC11360 from Abgent, a WuXi AppTec company Prices $452.25 Sizes 10 µg Species Human Accession BC001601

GAPDH cDNA (ANA10298) - ANA10298 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC026907

GAPDH cDNA (ANA10449) - ANA10449 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC009081

GAPDH cDNA (ANA10450) - ANA10450 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC009081

GAPDH cDNA (ANA11655) - ANA11655 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC029618

GAPDH - MBS1268250 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC001601

Human GAPDH ORF Clone(NM_002046.4) - CDCL164334 from Creative Biomart Species Human Accession NM_002046.4

Human GAPDH ORF clone - CDCL110617 from Creative Biomart Species Human Accession NM_001256799

Human GAPDH ORF clone - CDCL110618 from Creative Biomart Species Human Accession NM_001256799

Human GAPDH ORF clone - CDCL110619 from Creative Biomart Species Human Accession NM_001256799

Human GAPDH ORF clone - CDCL110620 from Creative Biomart Species Human Accession NM_001256799

Human GAPDH Gene ORF cDNA clone in cloning vector - HG10094-G from Sino Biological Species Human

Human GAPDH Gene ORF cDNA clone expression plasmid, C-HA tag - HG10094-CY from Sino Biological Species Human

Human GAPDH Gene ORF cDNA clone expression plasmid - HG10094-UT from Sino Biological Species Human

Human GAPDH Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10094-M-N from Sino Biological Species Human Accession NM_002046.3

Human GAPDH Gene ORF cDNA clone expression plasmid, C-His tag - HG10094-CH from Sino Biological Species Human

Human GAPDH Gene ORF cDNA clone expression plasmid, N-HA tag - HG10094-NY from Sino Biological Species Human

Human GAPDH Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10094-NF from Sino Biological Species Human

Human GAPDH Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10094-CF from Sino Biological Species Human

Human GAPDH Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10094-ACG from Sino Biological Species Human

Human GAPDH Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10094-NM from Sino Biological Species Human

Human GAPDH Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10094-CM from Sino Biological Species Human

Human GAPDH Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10094-ACR from Sino Biological Species Human

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