GAPDH

Gene Symbol	GAPDH
Entrez Gene	2597
Alt Symbol	G3PD, GAPD, HEL-S-162eP
Species	Human
Gene Type	protein-coding
Description	glyceraldehyde-3-phosphate dehydrogenase
Other Description	aging-associated gene 9 protein|epididymis secretory sperm binding protein Li 162eP|peptidyl-cysteine S-nitrosylase GAPDH
Swissprots	E7EUT4 Q53X65 P00354 P04406
Accessions	AAA53191 AAP88932 AEQ28035 AEQ28036 AEQ28037 EAW88786 EAW88787 P04406 AB062273 BAB93466 AF261085 AAF99678 AJ844644 CAH59755 AJ844645 CAH59756 AK026525 AK299448 BAG61421 AK308198 AY007133 AAG01996 AY633612 AAV33305 BC001601 AAH01601 BC004109 AAH04109 BC009081 AAH09081 BC013310 AAH13310 BC020308 BC023632 AAH23632 BC025925 AAH25925 BC026907 AAH26907 BC029340 BC029618 AAH29618 BC083511 AAH83511 BE893087 BG724119 BI463134 BM763361 BT006893 AAP35539 BU155402 CR407671 CAG28599 DQ403057 ABD77190 DQ891557 ABM82483 DQ894744 ABM85670 EF036498 ABO65084 EU668321 ACF94474 HQ727992 AET97565 HY000136 HY004110 HY022295 HY046784 J02642 AAA52496 M17851 AAA86283 M28283 AAA52519 M33197 AAA52518 M36164 X01677 CAA25833 X53778 CAA37794 NM_001256799 NP_001243728 NM_001289745 NP_001276674 NM_001289746 NP_001276675 NM_002046 NP_002037
Function	Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D- glyceroyl phosphate. Component of the GAIT (gamma interferon- activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibit
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:12829261}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12829261}. Membrane {ECO:0000269|PubMed:12829261}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Translocates to the nucleus following S- nitrosylation and interaction with SIAH1, which contains a nuclear localization signal (By similarity). Postnuclear and Perinuclear regions. {ECO:0000250}.
Top Pathways	Glycolysis / Gluconeogenesis, Alzheimer's disease, Biosynthesis of amino acids, Carbon metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human GAPDH full length protein - ab82633 from Abcam Category Protein Prices $192.00 Sizes 500 µg Source E. coli Species Human

Human GAPDH full length protein - ab77109 from Abcam Category Protein Source E. coli Species Human

Human GAPDH full length protein - ab190398 from Abcam Category Protein Source E. coli Species Human

Human GAPDH peptide - ab39759 from Abcam Category Peptide Species Human

Mouse GAPDH full length protein - ab202148 from Abcam Category Protein Source E. coli Species Mouse

Rabbit GAPDH full length protein - ab95174 from Abcam Category Protein Source Native Species Rabbit

GAPDH Antibody Blocking Peptide - LS-E14614 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GAPDH Antibody Blocking Peptide - LS-E14613 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GAPDH Antibody Blocking Peptide - LS-E14623 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GAPDH Antibody Blocking Peptide - LS-E25727 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GAPDH Antibody Blocking Peptide - LS-E30229 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GAPDH Antibody Blocking Peptide - LS-E30230 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GAPDH Antibody Blocking Peptide - LS-E21436 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GAPDH Antibody Blocking Peptide - LS-E21437 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GAPDH Antibody Blocking Peptide - LS-E21438 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GAPDH Antibody Blocking Peptide - LS-E26015 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GAPDH Antibody Blocking Peptide - LS-E9333 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GAPDH Antibody Blocking Peptide - LS-E9334 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GAPDH Protein - H00002597-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GAPDH Recombinant Protein - H00002597-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GAPDH Partial Recombinant Protein - H00002597-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human GAPDH Protein - NBC1-18528 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

GAPDH Recombinant Protein - P4547 from Novus Biologicals Category Protein Prices $449.00 Sizes 500 µg Species Human

Recombinant Human GAPDH Protein - NBP1-99538 from Novus Biologicals Category Protein Prices $225.00 Sizes 20 µg Source E. coli Species Human

GAPDH-Antibody-C-term-R248-Blocking-Peptide - BP7873b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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