DVL2

Gene Symbol DVL2
Entrez Gene 1856
Alt Symbol -
Species Human
Gene Type protein-coding
Description dishevelled segment polarity protein 2
Other Description dishevelled 2 (homologous to Drosophila dsh)|dishevelled, dsh homolog 2|segment polarity protein dishevelled homolog DVL-2
Swissprots Q53XM0 O14641 D3DTN3
Accessions EAW90244 EAW90245 O14641 AF006012 AAB65243 AK026019 AK297099 BAG59612 AK297285 BAG59756 AK304229 BAG65098 AK309771 AK312829 BC014844 AAH14844 BG716400 BT009822 AAP88824 CB994349 JF432818 ADZ16035 XM_005256502 XP_005256559 XM_006721469 XP_006721532 NM_004422 NP_004413
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). {ECO:0000250}.
Top Pathways Wnt signaling pathway, Notch signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection

DVL2 (Human) IP-WB Antibody Pair - H00001856-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

dishevelled, dsh homolog 2 (Drosophila) , ELISA Kit - MBS9332533 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human DVL2 ELISA Kit - E012053 from Biobool

Category ELISA Kit
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