DVL2

Gene Symbol DVL2
Entrez Gene 1856
Alt Symbol -
Species Human
Gene Type protein-coding
Description dishevelled segment polarity protein 2
Other Description dishevelled 2 (homologous to Drosophila dsh)|dishevelled, dsh homolog 2|segment polarity protein dishevelled homolog DVL-2
Swissprots Q53XM0 O14641 D3DTN3
Accessions EAW90244 EAW90245 O14641 AF006012 AAB65243 AK026019 AK297099 BAG59612 AK297285 BAG59756 AK304229 BAG65098 AK309771 AK312829 BC014844 AAH14844 BG716400 BT009822 AAP88824 CB994349 JF432818 ADZ16035 XM_005256502 XP_005256559 XM_006721469 XP_006721532 NM_004422 NP_004413
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). {ECO:0000250}.
Top Pathways Wnt signaling pathway, Notch signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection

Dvl-2 CRISPR/Cas9 KO Plasmid (h) - sc-400571 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dvl-2 HDR Plasmid (h) - sc-400571-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dvl-2 Double Nickase Plasmid (h) - sc-400571-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dvl-2 Double Nickase Plasmid (h2) - sc-400571-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dvl-2 CRISPR Activation Plasmid (h) - sc-400571-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dvl-2 CRISPR Activation Plasmid (h2) - sc-400571-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dvl-2 Lentiviral Activation Particles (h) - sc-400571-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dvl-2 Lentiviral Activation Particles (h2) - sc-400571-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dvl-2 siRNA (h) - sc-35230 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dvl-2 shRNA Plasmid (h) - sc-35230-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dvl-2 shRNA (h) Lentiviral Particles - sc-35230-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU012201 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7577 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7577 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04570 from Sigma-Aldrich

Category miRNA

DVL2 siRNA (Human) - CRH1302 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Dishevelled 2 - MBS826832 from MyBioSource

Prices $255.00
Sizes 5 od
Species Reactivities Human

DVL2 - MBS8232727 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DVL2 (NM_004422.2) - SHH282033 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DVL2(NM_004422.2) - SHH019847 from Creative biogene

Category siRNA
Species Reactivities Human

Dishevelled 2 siRNA - orb219174 from Biorbyt

Category siRNA
Prices $417.00
Sizes 5 od (260 nm)
Species Reactivities Human

Human DVL2 siRNA - orb261804 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DVL2 shRNA Plasmid (Human) - CHH1302 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DVL2 miRNA 3'UTR clone - MiUTR1H-03051 from Creative biogene

Species Reactivities Human
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