| Gene Symbol |
Tnfsf12
|
| Entrez Gene |
21944
|
| Alt Symbol |
Apo3l, Dr3l, Dr3lg, Tweak
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor (ligand) superfamily, member 12
|
| Other Description |
TNF-related weak inducer of apoptosis|tumor necrosis factor ligand superfamily member 12
|
| Swissprots |
O54907 Q9CTP2
|
| Accessions |
CAI51948 O54907 AF030100 AAC53517 AK020909 BAB32249 AK170297 BAE41696 AK171014 BAE42185 BC152795 AAI52796 BX634398 CB204861 CB848966 NM_011614 NP_035744
|
| Function |
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed.
|
| Top Pathways |
Cytokine-cytokine receptor interaction
|