Gene Symbol | Tnfsf12 |
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Entrez Gene | 21944 |
Alt Symbol | Apo3l, Dr3l, Dr3lg, Tweak |
Species | Mouse |
Gene Type | protein-coding |
Description | tumor necrosis factor (ligand) superfamily, member 12 |
Other Description | TNF-related weak inducer of apoptosis|tumor necrosis factor ligand superfamily member 12 |
Swissprots | O54907 Q9CTP2 |
Accessions | CAI51948 O54907 AF030100 AAC53517 AK020909 BAB32249 AK170297 BAE41696 AK171014 BAE42185 BC152795 AAI52796 BX634398 CB204861 CB848966 NM_011614 NP_035744 |
Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed. |
Top Pathways | Cytokine-cytokine receptor interaction |
Recombinant Mouse TWEAK/TNFSF12 - 1237-TW-025 from R&D Systems
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Recombinant Mouse TWEAK/TNFSF12, CF - 1237-TW-025/CF from R&D Systems
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Mouse TNFSF12 (Fc Tag) protein - orb232604 from Biorbyt
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TWEAK, Human, Recombinant - 28-10335 from ARP American Research Products
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Recombinant Mouse Tnfsf12, Met & His-tagged - Tnfsf12-983M from Creative Biomart
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Recombinant Mouse Tnfsf12, FLAG-tagged - Tnfsf12-196M from Creative Biomart
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Recombinant Mouse TWEAK - TWEAK-85M from Creative Biomart
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Mouse TNFSF12 Protein (Fc Tag) - 50174-M01H-50 from Sino Biological
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Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 12 (TNFSF12) - RPD933Mu01 from Cloud-clone
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Recombinant Mouse Tumor necrosis factor ligand superfamily member 12(Tnfsf12) - CSB-YP023987MO CSB-EP023987MO CSB-BP023987MO CSB-MP023987MO from Cusabio
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Recombinant Mouse TWEAK/TNFSF12 Protein, CF - 1237-TW/CF from R&D Systems
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Recombinant Mouse TWEAK/TNFSF12 Protein - 1237-TW from R&D Systems
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Mouse TWEAK (TNFSF12) Recombinant Protein - 25 micrograms - RP0898M-025 from Kingfisher Biotech
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Mouse TWEAK (TNFSF12) Recombinant Protein - 5 micrograms - RP0898M-005 from Kingfisher Biotech
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Recombinant Mouse TNFSF12 Protein - TNFSF12-17173M from Creative Biomart
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TNFSF12 Recombinant Protein (OPCD07583) - OPCD07583 from Aviva Systems Biology
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Mouse TNFSF12 Protein (Fc Tag) - 50174-M01H from ABclonal
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Recombinant Mouse TNFSF12 Protein (Arg105-His249), RlgG Fc-tagged - TNFSF12-810M from Creative Biomart
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