Gene Symbol | Tnfsf12 |
---|---|
Entrez Gene | 21944 |
Alt Symbol | Apo3l, Dr3l, Dr3lg, Tweak |
Species | Mouse |
Gene Type | protein-coding |
Description | tumor necrosis factor (ligand) superfamily, member 12 |
Other Description | TNF-related weak inducer of apoptosis|tumor necrosis factor ligand superfamily member 12 |
Swissprots | O54907 Q9CTP2 |
Accessions | CAI51948 O54907 AF030100 AAC53517 AK020909 BAB32249 AK170297 BAE41696 AK171014 BAE42185 BC152795 AAI52796 BX634398 CB204861 CB848966 NM_011614 NP_035744 |
Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed. |
Top Pathways | Cytokine-cytokine receptor interaction |