Vtcn1

Gene Symbol Vtcn1
Entrez Gene 242122
Alt Symbol B7h4, B7s1, B7x, BC032925
Species Mouse
Gene Type protein-coding
Description V-set domain containing T cell activation inhibitor 1
Other Description B7 homolog 4|V-set domain containing T-cell activation inhibitor 1|immune costimulatory protein B7-H4|t cell costimulatory molecule B7x|vtcn1
Swissprots Q8K091 Q7TSP5 Q7TPH5
Accessions EDL07635 Q7TSP5 AK143276 BAE25330 AK145664 BAE26576 AY280973 AAP37284 AY322147 AAP88965 AY346099 AAQ24205 BC032925 AAH32925 NM_178594 NP_848709
Function Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7Z7D3, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}; Lipid- anchor, GPI-anchor {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}.
Tissue Specificity Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}.
Top Pathways Cell adhesion molecules (CAMs)

B7-H4 (9) - sc-66189 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal

Anti-B7H4 antibody - ab138371 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-B7H4 antibody (ab138371) at 1 µg/mlLane 1 : Mouse Placenta Tissue LysateLane 2 : Testis (Mouse) Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-B7H4 antibody [188] - ab135262 from Abcam

Prices $376.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 188
Staining of non-transfected (left) and mouse B7H4 transfected (right) L5178Y cells with 0.25 µg of rat IgG2b kappa Isotype Control Purified (open histogram) or 0.25 µg of ab135262 (filled histogram), followed by Anti-rat IgG Biotin and Streptavidin PE. Total viable cells were used for analysis.

Anti-B7H4 antibody [188] - Low endotoxin, Azide free - ab185740 from Abcam

Prices $376.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone 188
Flow cytometric analysis of  non-transfected (left) and mouse B7H4 transfected (right) L5178Y cells labeling B7H4 with 0.25 µg ab185740 (filled histogram) or 0.25 µg rat IgG2b Isotype Control (open histogram). Detection utilised anti-rat IgG biotin and streptavidin PE. Total viable cells were used for analysis.

B7-H4 Antibody (188) - NBP1-43266 from Novus Biologicals

Prices $259.00, $369.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 188
Flow Cytometry: B7-H4 Antibody (188) [NBP1-43266] - Staining of non-transfected (left) and mouse B7-H4 transfected (right) L5178Y cells with 0.25 ug Rat IgG2b kappa Isotype Control Purified (open histogram) or 0.25 ug Anti-Mouse B7-H4 Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE. Total viable cells were used for analysis.

B7H4 antibody - 10R-6582 from Fitzgerald

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone H74

B7H4 antibody (PE) - 61R-1382 from Fitzgerald

Prices $250.00, $485.00
Sizes 25 tests, 100 tests
Host Mouse
Clonality Monoclonal
Clone H74

B7H4 antibody (biotin) - 61R-1626 from Fitzgerald

Prices $235.00
Sizes 25 µg
Host Mouse
Clonality Monoclonal
Clone H74

PE anti-mouse B7-H4 (B7S1, B7X) Antibody - 128107 from Biolegend

Prices $110.00
Sizes 50 µg
Host Rat
Clone clone 9
Mouse B7-H4 transfected 293E cells stained with clone 9 PE

APC anti-mouse B7-H4 (B7S1, B7X) Antibody - 139407 from Biolegend

Prices $120.00, $315.00
Sizes 25 µg, 100 µg
Host Hamster
Clone HMH4-5G1
B7-H4 transfected 293 cells were stained with B7-H4 (clone HMH4-5G1) APC (filled histogram) or Armenian hamster IgG APC isotype control (open histogram).

LEAF™ Purified anti-mouse B7-H4 (B7S1, B7X) Antibody - 139404 from Biolegend

Prices $495.00
Sizes 500 µg
Host Hamster
Clone HMH4-5G1
Mouse B7-H4 transfected 293 cells stained with purified HMH4-5G1 conjugated with PE

PE anti-mouse B7-H4 (B7S1, B7X) Antibody - 139405 from Biolegend

Prices $120.00, $315.00
Sizes 25 µg, 100 µg
Host Hamster
Clone HMH4-5G1
Mouse B7-H4 transfected 293 cells stained with HMH4-5G1 PE

Anti-VTCN1 antibody - STJ72722 from St John's Laboratory Ltd

Host Goat
Clonality Polyclonal

Anti-B7-H4 antibody - STJ71250 from St John's Laboratory Ltd

Host Goat
Clonality Polyclonal

Rat anti-B7H4 Monoclonal antibody [clone 299] - DCABH-3216 from Creative Diagnostics

Host Rat
Clonality Monoclonal
Clone 299

Anti-VTCN1 monoclonal antibody, clone 299 - DCABH-7969 from Creative Diagnostics

Host Rat
Clonality Monoclonal
Clone 299

Rabbit Anti-Human VTCN1 Polyclonal antibody - DPABH-27257 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

B7-H4 Antibody (188), PE conjugate, Molecular Probes™ - A18534 from Thermo Fisher Scientific

Prices $96.00
Sizes 25 µg
Host Rat
Clonality Monoclonal
Clone 188

VTCN1 / B7H4 antibody - TA320512 from Acris Antibodies

Prices $120.00
Sizes 25 µg
Host Rat
Clonality Monoclonal
Clone 188
Staining of non-transfected (left) and mouse B7-H4 transfected (right) L5178Y cells with 0.25 ug Rat IgG2b kappa Isotype Control Purified (open histogram) or 0.25 ug Anti-Mouse B7-H4 Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE . Total viable cells were used for analysis.

Anti-VTCN1 Monoclonal antibody, clone 299 [PE] - CABT-BL8421 from Creative Diagnostics

Host Rat
Clonality Monoclonal
Clone 299

Recombinant Rat Anti-Vtcn1 Antibody (188) - NEUT-2275CQ from Creative Biolabs

Host Rat
Clone 188

B7-H4, Polyclonal Antibody - MBS668518 from MyBioSource

Prices $140.00, $270.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
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