| Gene Symbol |
Vtcn1
|
| Entrez Gene |
242122
|
| Alt Symbol |
B7h4, B7s1, B7x, BC032925
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
V-set domain containing T cell activation inhibitor 1
|
| Other Description |
B7 homolog 4|V-set domain containing T-cell activation inhibitor 1|immune costimulatory protein B7-H4|t cell costimulatory molecule B7x|vtcn1
|
| Swissprots |
Q8K091 Q7TSP5 Q7TPH5
|
| Accessions |
EDL07635 Q7TSP5 AK143276 BAE25330 AK145664 BAE26576 AY280973 AAP37284 AY322147 AAP88965 AY346099 AAQ24205 BC032925 AAH32925 NM_178594 NP_848709
|
| Function |
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7Z7D3, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}; Lipid- anchor, GPI-anchor {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}.
|
| Tissue Specificity |
Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|