Vtcn1

Gene Symbol	Vtcn1
Entrez Gene	242122
Alt Symbol	B7h4, B7s1, B7x, BC032925
Species	Mouse
Gene Type	protein-coding
Description	V-set domain containing T cell activation inhibitor 1
Other Description	B7 homolog 4|V-set domain containing T-cell activation inhibitor 1|immune costimulatory protein B7-H4|t cell costimulatory molecule B7x|vtcn1
Swissprots	Q8K091 Q7TSP5 Q7TPH5
Accessions	EDL07635 Q7TSP5 AK143276 BAE25330 AK145664 BAE26576 AY280973 AAP37284 AY322147 AAP88965 AY346099 AAQ24205 BC032925 AAH32925 NM_178594 NP_848709
Function	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7Z7D3, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}; Lipid- anchor, GPI-anchor {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}.
Tissue Specificity	Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Mouse B7-H4, CF - 2154-B7-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Phe29-Pro258, with a C-terminal 10-His tag

Recombinant Mouse B7-H4 Fc Chimera, CF - 4206-B7-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Mouse VTCN1 protein - orb179708 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Mouse

Mouse B7-H4 protein - orb138236 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Mouse

Recombinant Mouse Vtcn1 - Vtcn1-13M from Creative Biomart Category Protein Source Human Cells Species Mouse

Recombinant Mouse VTCN1, MIgG2a Fc-tagged - VTCN1-533H from Creative Biomart Category Protein Source CHO cells Species Mouse

Recombinant Mouse Vtcn1, Fc-tagged - Vtcn1-12M from Creative Biomart Category Protein Source CHO cells Species Mouse

Recombinant Mouse Vtcn1, Fc Chimera - Vtcn1-410M from Creative Biomart Category Protein Source NSO cells Species Mouse

Mouse B7-H4 Recombinant - RKQ7TSP5 from Reprokine Category Protein Prices $160.00, $480.00, $1,950.00 Sizes 20 µg, 100 µg, 500 µg Source Optimized DNA sequence encoding mature chain of mouse B7-H4 (PHE29 - SER256) including a C-terminal His tag was expressed in HEK293 cells. Species Mouse

Mouse B7-H4 / B7S1 / B7x / VTCN1 Protein - 50017-MCCH-100 from Sino Biological Category Protein Source Human Cells Species Mouse

Mouse B7-H4 / B7S1 / B7x Protein (Fc Tag) - 50017-M02H-50 from Sino Biological Category Protein Source Human Cells Species Mouse

Recombinant Mouse V-set domain containing T-cell activation inhibitor 1(Vtcn1) - CSB-YP742524MO CSB-EP742524MO CSB-BP742524MO CSB-MP742524MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Recombinant Mouse B7-H4 His-tag Protein, CF - 2154-B7 from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Phe29-Pro258, with a C-terminal 10-His tag Species Mouse

Recombinant Mouse B7-H4 Fc Chimera Protein, CF - 4206-B7 from R&D Systems Category Protein Prices $349.00, $2,360.00 Sizes 100 µg, 1 mg Source Mouse myeloma cell line, NS0-derived Mouse B7-H4 (Phe29-Pro258) Accession # AAP37284 IEGRMDP Mouse IgG 2a (Glu98-Lys330) N-terminus C-terminus Species Mouse

Recombinant Human B7-H4 Protein Fc Chimera, CF - 8870-B7 from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Human embryonic kidney cell, HEK293-derived Human B7-H4 (Phe29-Ala258) Accession # Q7Z7D3 IEGRMD Human IgG 1 (Pro100-Lys330) N-terminus C-terminus Species Human

V-set domain containing T-cell activation inhibitor 1 (Vtcn1) , Recombinant Protein - MBS1391080 from MyBioSource Category Protein Prices $1,495.00, $1,495.00, $1,955.00, $1,955.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Recombinant Mouse B7-H4:Fc Chimera - CRM034 from Cell Science Prices $472.00 Sizes 100 μg Species Mouse

Recombinant Mouse B7-H4 / B7S1 / B7x Protein (Fc tag) - PKSM040913 from Elabscience Category Protein Source Human Cell Species Mouse

Mouse B7-H4 protein - orb6055 from Biorbyt Category Protein Prices $281.00, $553.00, $1,700.00, $2,406.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Mouse

B7-H4 /VTCN1, mouse recombinant - P1107 from Biovision Category Protein Prices $85.00, $375.00 Sizes 10 μg, 50 µg Source CHO cells Species Mouse

Mouse B7-H4 / B7S1 / B7x Protein (Fc Tag) - 50017-M02H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Mouse

Mouse B7-H4 / B7S1 / B7x / VTCN1 Protein - 50017-MCCH from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Mouse

B7-H4 Recombinant Protein - 90-371 from ProSci Category Protein Prices $425.00 Sizes 100 µg Source CHO cells Species Mouse

B7-H4 / B7S1 / B7x, Recombinant Protein - MBS2547210 from MyBioSource Category Protein Prices $475.00, $775.00 Sizes 50 µg, 100 µg Source Human Cells

B7-H4 /VTCN1, Recombinant Protein - MBS847035 from MyBioSource Category Protein Prices $150.00, $450.00 Sizes 10 µg, 50 µg Source CHO cells Source: Mouse

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