Gene Symbol | Vtcn1 |
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Entrez Gene | 242122 |
Alt Symbol | B7h4, B7s1, B7x, BC032925 |
Species | Mouse |
Gene Type | protein-coding |
Description | V-set domain containing T cell activation inhibitor 1 |
Other Description | B7 homolog 4|V-set domain containing T-cell activation inhibitor 1|immune costimulatory protein B7-H4|t cell costimulatory molecule B7x|vtcn1 |
Swissprots | Q8K091 Q7TSP5 Q7TPH5 |
Accessions | EDL07635 Q7TSP5 AK143276 BAE25330 AK145664 BAE26576 AY280973 AAP37284 AY322147 AAP88965 AY346099 AAQ24205 BC032925 AAH32925 NM_178594 NP_848709 |
Function | Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. {ECO:0000250|UniProtKB:Q7Z7D3, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}; Lipid- anchor, GPI-anchor {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}. |
Tissue Specificity | Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:12818166, ECO:0000269|PubMed:12920180}. |
Top Pathways | Cell adhesion molecules (CAMs) |
B7-H4 CRISPR/Cas9 KO Plasmid (m) - sc-433877 from Santa Cruz Biotechnology
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B7-H4 HDR Plasmid (m) - sc-433877-HDR from Santa Cruz Biotechnology
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B7-H4 Double Nickase Plasmid (m) - sc-433877-NIC from Santa Cruz Biotechnology
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B7-H4 Double Nickase Plasmid (m2) - sc-433877-NIC-2 from Santa Cruz Biotechnology
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B7-H4 CRISPR Activation Plasmid (m) - sc-433877-ACT from Santa Cruz Biotechnology
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B7-H4 CRISPR Activation Plasmid (m2) - sc-433877-ACT-2 from Santa Cruz Biotechnology
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B7-H4 Lentiviral Activation Particles (m) - sc-433877-LAC from Santa Cruz Biotechnology
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B7-H4 Lentiviral Activation Particles (m2) - sc-433877-LAC-2 from Santa Cruz Biotechnology
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B7-H4 siRNA (m) - sc-72385 from Santa Cruz Biotechnology
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B7-H4 shRNA Plasmid (m) - sc-72385-SH from Santa Cruz Biotechnology
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B7-H4 shRNA (m) Lentiviral Particles - sc-72385-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU055171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN44513 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND44513 from Sigma-Aldrich
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VTCN1 siRNA (Mouse) - CRN3581 from Cohesion Biosciences
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VTCN1 - MBS8221020 from MyBioSource
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shRNA set against Mouse VTCN1 (NM_178594.3) - SHH445348 from Creative biogene
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Mouse VTCN1 siRNA - orb293056 from Biorbyt
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VTCN1 shRNA Plasmid (Mouse) - CHN3581 from Cohesion Biosciences
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