| Gene Symbol |
Fos
|
| Entrez Gene |
14281
|
| Alt Symbol |
D12Rfj1, c-fos, cFos
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
FBJ osteosarcoma oncogene
|
| Other Description |
cellular oncogene fos|proto-oncogene c-Fos|proto-oncogene protein c-fos
|
| Swissprots |
P01101
|
| Accessions |
AAA96699 CAA24105 EDL02869 EDL02870 EDL02871 P01101 AK154418 BAE32571 AK159688 AY423854 AAR00345 BC013242 BC029814 AAH29814 NM_010234 NP_034364
|
| Function |
Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000250, ECO:0000269|PubMed:12134156, ECO:0000269|PubMed:12972619, ECO:0000269|PubMed:15719069, ECO:0000269|PubMed:21998197, ECO:0000269|PubMed:22105363}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity). {ECO:0000250}.
|
| Top Pathways |
Toll-like receptor signaling pathway, cAMP signaling pathway, Circadian entrainment, TNF signaling pathway, Prolactin signaling pathway
|