| Gene Symbol | Fos |
|---|---|
| Entrez Gene | 14281 |
| Alt Symbol | D12Rfj1, c-fos, cFos |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | FBJ osteosarcoma oncogene |
| Other Description | cellular oncogene fos|proto-oncogene c-Fos|proto-oncogene protein c-fos |
| Swissprots | P01101 |
| Accessions | AAA96699 CAA24105 EDL02869 EDL02870 EDL02871 P01101 AK154418 BAE32571 AK159688 AY423854 AAR00345 BC013242 BC029814 AAH29814 NM_010234 NP_034364 |
| Function | Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000250, ECO:0000269|PubMed:12134156, ECO:0000269|PubMed:12972619, ECO:0000269|PubMed:15719069, ECO:0000269|PubMed:21998197, ECO:0000269|PubMed:22105363}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity). {ECO:0000250}. |
| Top Pathways | Toll-like receptor signaling pathway, cAMP signaling pathway, Circadian entrainment, TNF signaling pathway, Prolactin signaling pathway |
c-Fos CRISPR/Cas9 KO Plasmid (m) - sc-420400 from Santa Cruz Biotechnology
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c-Fos HDR Plasmid (m) - sc-420400-HDR from Santa Cruz Biotechnology
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c-Fos Double Nickase Plasmid (m) - sc-420400-NIC from Santa Cruz Biotechnology
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c-Fos Double Nickase Plasmid (m2) - sc-420400-NIC-2 from Santa Cruz Biotechnology
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c-Fos CRISPR Activation Plasmid (m) - sc-420400-ACT from Santa Cruz Biotechnology
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c-Fos CRISPR Activation Plasmid (m2) - sc-420400-ACT-2 from Santa Cruz Biotechnology
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c-Fos Lentiviral Activation Particles (m) - sc-420400-LAC from Santa Cruz Biotechnology
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c-Fos Lentiviral Activation Particles (m2) - sc-420400-LAC-2 from Santa Cruz Biotechnology
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c-Fos siRNA (m) - sc-29222 from Santa Cruz Biotechnology
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c-Fos shRNA Plasmid (m) - sc-29222-SH from Santa Cruz Biotechnology
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c-Fos shRNA (m) Lentiviral Particles - sc-29222-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU025381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31484 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31484 from Sigma-Aldrich
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FOS siRNA (Mouse) - CRM1410 from Cohesion Biosciences
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FOS - MBS829666 from MyBioSource
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shRNA set against Mouse FOS (NM_010234.2) - SHH296317 from Creative biogene
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shRNA set against Mouse Fos(NM_010234.2) - SHH065459 from Creative biogene
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Mouse FOS siRNA - orb280886 from Biorbyt
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FOS shRNA Plasmid (Mouse) - CHM1410 from Cohesion Biosciences
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FOS miRNA 3'UTR clone - MiUTR1M-04763 from Creative biogene
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