FOXO3

Gene Symbol	FOXO3
Entrez Gene	2309
Alt Symbol	AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
Species	Human
Gene Type	protein-coding
Description	forkhead box O3
Other Description	forkhead box O3A|forkhead box protein O3|forkhead homolog (rhabdomyosarcoma) like 1|forkhead in rhabdomyosarcoma-like 1|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
Swissprots	Q9BZ04 O43524 Q5T2I7 E1P5E6 O15171 B4DVZ6
Accessions	CAA04861 EAW48373 EAW48374 O43524 AB072905 AF032886 AAC39592 AI554317 AJ001589 CAA04860 AK024103 AK092357 AK122861 AK301304 BAG62858 AK303933 BAG64861 AK311587 BC020227 AAH20227 BC021224 AAH21224 BC045800 BC068552 AAH68552 CA389775 CD101760 CR749261 CAH18117 XM_005266867 XP_005266924 XM_005266868 XP_005266925 XM_011535626 XP_011533928 XM_011535627 XP_011533929 XM_011535628 XP_011533930 XM_011535629 XP_011533931 NM_001455 NP_001446 NM_201559 NP_963853
Function	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882}.
Subcellular Location	Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:9479491}.
Top Pathways	Non-small cell lung cancer, Endometrial cancer, Neurotrophin signaling pathway, Chemokine signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-FOXO3 / FOXO3A (Ser253) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1512 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat FOXO3 / FOXO3A ELISA Kit (Cell-Based ELISA) - LS-F1993 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat FOXO3 / FOXO3A ELISA Kit (DNA-Binding ELISA) - LS-F760 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human Phospho-FOXO3 / FOXO3A (Ser253) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F874 from LifeSpan Bioscience Category ELISA Kit Prices $750.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse FOXO3 / FOXO3A ELISA Kit (Sandwich ELISA) - LS-F7348 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.054 ng/ml Range 0.313-20 ng/ml

Human FOXO3 / FOXO3A ELISA Kit (Sandwich ELISA) - LS-F11487 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Rabbit anti-FOXO3a Antibody, Affinity Purified - PLA0107 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human Forkhead Box O3 ELISA Kit - abx052379 from Abbexa Category ELISA Kit

Forkhead box O3, FOXO3, Human, ELISA Kit - CSB-E11177h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.39 pg/ml Range 1.56 pg/ml -100 pg/ml

Forkhead box protein O3, FOXO3, Human, ELISA Kit - E0762h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Forkhead Box Protein O2, FOXO2, Human, ELISA Kit - E-EL-H1100 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Forkhead Box Protein O3, FOXO3, Human, ELISA Kit - E-EL-H1101 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Forkhead Box Protein O2, FOXO2, Rabbit, ELISA Kit - E-EL-RB2080 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Forkhead Box Protein O3, FOXO3, Rabbit, ELISA Kit - E-EL-RB0150 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Forkhead Box Protein O2, FOXO2, Chicken, ELISA Kit - E-EL-Ch1100 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Forkhead Box Protein O3, FOXO3, Chicken, ELISA Kit - E-EL-Ch1574 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Forkhead Box Protein O2, FOXO2, Porcine, ELISA Kit - E-EL-P1511 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Forkhead Box Protein O3, FOXO3, Porcine, ELISA Kit - E-EL-P2137 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Forkhead Box Protein O3, FOXO3, Sheep, ELISA Kit - E-EL-S0557 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Forkhead Box Protein O2, FOXO2, Monkey, ELISA Kit - E-EL-MK2013 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Forkhead Box Protein O3, FOXO3, Monkey, ELISA Kit - E-EL-MK1906 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human FOXO3 ELISA Kit - HF0124 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine FOXO3 ELISA Kit - AF0124 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

FKHRL1 Colorimetric Cell-Based ELISA Kit - CB5269 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

FKHRL1 (Phospho-Ser253) Colorimetric Cell-Based ELISA Kit - CBP1558 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

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