FOXO3

Gene Symbol	FOXO3
Entrez Gene	2309
Alt Symbol	AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
Species	Human
Gene Type	protein-coding
Description	forkhead box O3
Other Description	forkhead box O3A|forkhead box protein O3|forkhead homolog (rhabdomyosarcoma) like 1|forkhead in rhabdomyosarcoma-like 1|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
Swissprots	Q9BZ04 O43524 Q5T2I7 E1P5E6 O15171 B4DVZ6
Accessions	CAA04861 EAW48373 EAW48374 O43524 AB072905 AF032886 AAC39592 AI554317 AJ001589 CAA04860 AK024103 AK092357 AK122861 AK301304 BAG62858 AK303933 BAG64861 AK311587 BC020227 AAH20227 BC021224 AAH21224 BC045800 BC068552 AAH68552 CA389775 CD101760 CR749261 CAH18117 XM_005266867 XP_005266924 XM_005266868 XP_005266925 XM_011535626 XP_011533928 XM_011535627 XP_011533929 XM_011535628 XP_011533930 XM_011535629 XP_011533931 NM_001455 NP_001446 NM_201559 NP_963853
Function	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882}.
Subcellular Location	Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:9479491}.
Top Pathways	Non-small cell lung cancer, Endometrial cancer, Neurotrophin signaling pathway, Chemokine signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FOXO3A (phospho S253) peptide - ab27885 from Abcam Category Peptide

Human FOXO3A (phospho T32) peptide - ab27877 from Abcam Category Peptide

Human FOXO3A (unmodified ) peptide - ab27884 from Abcam Category Peptide

Human FOXO3A full length protein - ab114191 from Abcam Category Protein Source Wheat germ Species Human

Human FOXO3A peptide - ab24031 from Abcam Category Peptide

Human FOXO3A peptide - ab27878 from Abcam Category Peptide

Human FOXO3A peptide - ab45581 from Abcam Category Peptide Species Human

Human FOXO3A protein fragment - ab158451 from Abcam Category Protein Source Wheat germ Species Human

FOXO3 / FOXO3A Antibody Blocking Peptide - LS-E2342 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXO3 / FOXO3A Antibody Blocking Peptide - LS-E3033 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXO3 / FOXO3A Antibody Blocking Peptide - LS-E25733 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXO3 / FOXO3A Antibody Blocking Peptide - LS-E30948 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FOXO3 / FOXO3A Antibody Blocking Peptide - LS-E13643 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FOXO3 Protein - H00002309-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FOXO3 Recombinant Protein - H00002309-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FOXO3 Blocking Peptide - NBP1-77380PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

FOXO3-Antibody-N-term-Blocking-peptide - BP13306a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOXO3-Antibody-Center-Blocking-Peptide - BP14166c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOXO3A/FOXO3/FKHRL1 blocking peptide - GTX17026-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Human FOXO3 protein - orb245839 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

FOXO3a Blocking Peptide - 33R-10870 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

FOXO3A Blocking Peptide - 33R-5961 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FOXO3A Peptide - AC21-0562-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FOXO3 / FKHRL1 - H00002309-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FOXO3 / FKHRL1 - H00002309-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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