FOXO3

Gene Symbol FOXO3
Entrez Gene 2309
Alt Symbol AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
Species Human
Gene Type protein-coding
Description forkhead box O3
Other Description forkhead box O3A|forkhead box protein O3|forkhead homolog (rhabdomyosarcoma) like 1|forkhead in rhabdomyosarcoma-like 1|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
Swissprots Q9BZ04 O43524 Q5T2I7 E1P5E6 O15171 B4DVZ6
Accessions CAA04861 EAW48373 EAW48374 O43524 AB072905 AF032886 AAC39592 AI554317 AJ001589 CAA04860 AK024103 AK092357 AK122861 AK301304 BAG62858 AK303933 BAG64861 AK311587 BC020227 AAH20227 BC021224 AAH21224 BC045800 BC068552 AAH68552 CA389775 CD101760 CR749261 CAH18117 XM_005266867 XP_005266924 XM_005266868 XP_005266925 XM_011535626 XP_011533928 XM_011535627 XP_011533929 XM_011535628 XP_011533930 XM_011535629 XP_011533931 NM_001455 NP_001446 NM_201559 NP_963853
Function Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882}.
Subcellular Location Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:9479491}.
Top Pathways Non-small cell lung cancer, Endometrial cancer, Neurotrophin signaling pathway, Chemokine signaling pathway, PI3K-Akt signaling pathway

FOXO3 - MBS1274669 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC020227

Human FOXO3 ORF clone - CDCL109307 from Creative Biomart

Species Human
Accession NM_001455

Human FOXO3 ORF clone - CDCL109308 from Creative Biomart

Species Human
Accession NM_001455

Mouse FOXO3 ORF clone - CDCL109309 from Creative Biomart

Species Human
Accession NM_001455

Mouse FOXO3 ORF clone - CDCL109310 from Creative Biomart

Species Human
Accession NM_001455

Human FOXO3 ORF Clone(NM_001455.3) - CDCL163944 from Creative Biomart

Species Human
Accession NM_001455.3

Human FOXO3 ORF Clone(NM_001455.3) - CDCL163945 from Creative Biomart

Species Human
Accession NM_001455.3

Human FOXO3 ORF Clone (BC020227) - CDCS410282 from Creative biogene

Species Human
Accession O43524
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