FOXO3

Gene Symbol	FOXO3
Entrez Gene	2309
Alt Symbol	AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
Species	Human
Gene Type	protein-coding
Description	forkhead box O3
Other Description	forkhead box O3A|forkhead box protein O3|forkhead homolog (rhabdomyosarcoma) like 1|forkhead in rhabdomyosarcoma-like 1|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
Swissprots	Q9BZ04 O43524 Q5T2I7 E1P5E6 O15171 B4DVZ6
Accessions	CAA04861 EAW48373 EAW48374 O43524 AB072905 AF032886 AAC39592 AI554317 AJ001589 CAA04860 AK024103 AK092357 AK122861 AK301304 BAG62858 AK303933 BAG64861 AK311587 BC020227 AAH20227 BC021224 AAH21224 BC045800 BC068552 AAH68552 CA389775 CD101760 CR749261 CAH18117 XM_005266867 XP_005266924 XM_005266868 XP_005266925 XM_011535626 XP_011533928 XM_011535627 XP_011533929 XM_011535628 XP_011533930 XM_011535629 XP_011533931 NM_001455 NP_001446 NM_201559 NP_963853
Function	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. {ECO:0000269|PubMed:10102273, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:21329882}.
Subcellular Location	Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:9479491}.
Top Pathways	Non-small cell lung cancer, Endometrial cancer, Neurotrophin signaling pathway, Chemokine signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® FoxO3a siRNA I - 6302 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® FoxO3a siRNA II - 6303 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

FKHRL1 CRISPR/Cas9 KO Plasmid (h) - sc-400308 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FKHRL1 HDR Plasmid (h) - sc-400308-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FKHRL1 Double Nickase Plasmid (h) - sc-400308-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FKHRL1 Double Nickase Plasmid (h2) - sc-400308-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FKHRL1 CRISPR Activation Plasmid (h) - sc-400308-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FKHRL1 CRISPR Activation Plasmid (h2) - sc-400308-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FKHRL1 Lentiviral Activation Particles (h) - sc-400308-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FKHRL1 Lentiviral Activation Particles (h2) - sc-400308-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

FKHRL1 siRNA (h) - sc-37887 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FKHRL1 shRNA Plasmid (h)-SH - sc-37887-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FKHRL1 shRNA (h) Lentiviral Particles - sc-37887-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

FOXO3 RNAi - H00002309-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU113611 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1989 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1989 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

FOXO3 siRNA (Human) - CRH1616 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FOXO3 RNAi - H00002309-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

FOXO3 - MBS8232088 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FKHRL1 CRISPR/Cas9 KO Plasmid (h2) - sc-400308-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

FKHRL1 HDR Plasmid (h2) - sc-400308-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Human FOXO3 siRNA - orb262118 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FOXO3 shRNA Plasmid (Human) - CHH1616 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FOXO3 miRNA 3'UTR clone - MiUTR1H-03832 from Creative biogene Species Reactivities Human

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